Renal medullary oxidative stress, pressure-natriuresis, and hypertension.
Renal medullary oxidative stress, pressure-natriuresis, and hypertension.
复制标题
DOI：
10.1161/hypertensionaha.107.092858
复制
发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
Cowley AW Jr
中科院分区：
文献类型：
--
作者：
Cowley AW Jr
目前尚不清楚，但微穿刺研究表明，这种情况发生在深髓肾单位的Henle袢中，可能与髓质溶质梯度的冲刷有关，从而影响了这部分肾单位对钠的被动重吸收。一些研究人员在狗的肾灌注压和MBF之间发现了类似的关系，而另一些则没有。23然而，在大鼠身上进行的大量研究结果是一致的，尽管受到水合状态的影响，但这些结果表明，髓质血流的变化为压力-钠尿反应提供了信号，是长期控制钠排泄和动脉血压的重要环节。
sible for the remaining reduction of NaCl reabsorption are less clearly understood but micropuncture studies have demonstrated that this occurs in the loops of Henle of deep medullary nephrons and may be coupled to washout of the medullary solute gradient that affects the passive reabsorption of sodium in this portion of the nephron. 3 Some investigators have found similar relationships between renal perfusion pressure and MBF in dogs, 22 whereas others have not. 23 However, the results of numerous studies in rats have been consistent, and although influenced by the state of hydration these results indicate that changes of medullary blood flow provide the signal for the pressure-natriuresis response and are the vital link to the long-term control of sodium excretion and arterial blood pressure.