Genetic variation in IL28RA is associated with the outcomes of HCV infection in a high-risk Chinese population
Genetic variation in IL28RA is associated with the outcomes of HCV infection in a high-risk Chinese population
复制标题
IL28RA 的遗传变异与中国高危人群中 HCV 感染的结果相关。
DOI：
10.1016/j.meegid.2011.06.016
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发表时间：
2011-10-01
影响因子：
3.2
通讯作者：
Yu, Rong-Bin
中科院分区：
文献类型：
--
作者：
Cui, Qian;Zhang, Yong-Xiang;Yu, Rong-Bin
丙型肝炎病毒(丙型肝炎病毒)感染的结果因病毒和宿主因素而异。本研究旨在探讨IFNAR2、IL10RB和IL28RA基因的单核苷酸多态(SNPs)与丙型肝炎病毒感染易感性和病毒消退的关系。应用TaqMan(R)方法对552例抗-HCV阳性患者和421例非感染对照组的IFNAR2、IL10RB和IL28RA基因进行了基因分型。IFNAR2和IL10RB基因在对照组、持续感染组和自发清除组中的分布没有差异。IL-28RA-rs10903035A等位基因在持续感染组中的表达显著高于未感染对照组和自然清除组(OR=1.54，95%CI=1.23~1.92，P=0.004；OR=1.42，95%CI=1.12~1.81，P=0.016)。IL28RA-rs11249006GG基因型降低了丙型肝炎病毒持续感染的易感性(OR=0.53，95%CI=0.31~0.91，P=0.044)，且不同年龄和可能感染源的亚组之间的保护作用有显著差异(P<；0.05)。此外，AG基因对年轻人(老年人)中丙型肝炎病毒的自发清除有显著的负面影响
Hepatitis C virus (HCV) infection varies in the outcomes depending on both viral and host factors. This study aims to investigate the association of single-nucleotide polymorphisms (SNPs) of IFNAR2, IL10RB, and IL28RA genes with susceptibility to HCV infection and resolution. Genotyping of IFNAR2, IL10RB, and IL28RA gene polymorphisms were performed using TaqMan (R) method from 552 patients with seropositive anti-HCV and 421 uninfected controls. The distribution of IFNAR2 and IL10RB genotypes among the control, persistent infection, and spontaneous clearance groups did not differ. However, IL28RA-rs10903035 A allele was over-represented in persistent infection group when compared with uninfected controls and spontaneous clearance group, respectively (OR = 1.54, 95% CI = 1.23-1.92, P = 0.004; OR = 1.42, 95% CI = 1.12-1.81, P = 0.016), and AA genotype had a significant increased risk of persistent infection in different strata except for the females subgroup (P < 0.05). IL28RA-rs11249006 GG genotype showed reduced susceptibility to persistent HCV infection (OR = 0.53, 95% CI = 0.31-0.91, P = 0.044), and the protective effect was significantly different among subgroups stratified by age and likely source of infection (P < 0.05). Besides, AG genotype had a significant negative effect on spontaneous clearance of HCV among young subjects (aged