Rational Design of Conjugated Small Molecules for Superior Photothermal Theranostics in the NIR-II Biowindow
Rational Design of Conjugated Small Molecules for Superior Photothermal Theranostics in the NIR-II Biowindow
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DOI：
10.1002/adma.202001146
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发表时间：
2020-07-06
影响因子：
29.4
通讯作者：
Lee, Chun-Sing
中科院分区：
文献类型：
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作者：
Li, Shengliang;Deng, Qingyuan;Lee, Chun-Sing
有机光热剂由于具有良好的生物相容性，近年来在生物医学领域的设计和应用方面取得了广泛的进展。有机光热剂的进一步开发和应用的一个主要障碍是在第二近红外（NIR-II）窗口中的高性能材料的稀缺性，其允许深入组织渗透并导致最小化的副作用。到目前为止，报道的具有近红外-Ⅱ活性的光热剂很少，而且它们的光热转换效率也相对较低。在本文中，π共轭小分子从第一NIR窗口到NIR-II窗口的光学吸收通过取代单个原子的分子手术精确地调节。利用这种技术，共轭低聚物（IR-SS）的吸收峰超过1000 nm的第一个演示，其纳米粒子实现了创纪录的高光热转换效率为77%，在1064 nm的激发下。该纳米颗粒在体外和体内表现出良好的光声响应、光热治疗功效和生物相容性。这项工作开发了一种策略，以提高癌症治疗诊断学的NIR-II窗口中的光捕获效率，为推进NIR-II光热剂的设计和应用迈出了重要的一步。
Extensive recent progress has been made on the design and applications of organic photothermal agents for biomedical applications because of their excellent biocompatibility comparing with inorganic materials. One major hurdle for the further development and applications of organic photothermal agents is the rarity of high-performance materials in the second near-infrared (NIR-II) window, which allows deep tissue penetration and causes minimized side effects. Up till now, there have been few reported NIR-II-active photothermal agents and their photothermal conversion efficiencies are relatively low. Herein, optical absorption of pi-conjugated small molecules from the first NIR window to the NIR-II window is precisely regulated by molecular surgery of substituting an individual atom. With this technique, the first demonstration of a conjugated oligomer (IR-SS) with an absorption peak beyond 1000 nm is presented, and its nanoparticle achieves a record-high photothermal conversion efficiency of 77% under 1064 nm excitation. The nanoparticles show a good photoacoustic response, photothermal therapeutic efficacy, and biocompatibility in vitro and in vivo. This work develops a strategy to boost the light-harvesting efficiency in the NIR-II window for cancer theranostics, offering an important step forward in advancing the design and application of NIR-II photothermal agents.