Tamoxifen prevents sulpiride-induced weight gain in female rats
Tamoxifen prevents sulpiride-induced weight gain in female rats
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DOI：
10.1016/s0091-3057(96)00315-2
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发表时间：
1997-05-01
影响因子：
3.6
通讯作者：
Weiss, SR
中科院分区：
文献类型：
--
作者：
Baptista, T;DeBaptista, EA;Weiss, SR
为了评价它在对抗抗精神病药诱导的肥胖中的潜在效用，评估了长期施用他莫昔芬（TAM）对性腺完整和舒必利治疗（SUL）的雌性大鼠的体重（BW）和食物摄入（FI）的影响。此外，测定了SUL、SUL + TAM和SUL+溴隐亭（BR）处理的大鼠血清雌二醇和催乳素水平。TAM在10、50和100 μ g剂量下显著降低BW增益; FI在50和100 μ g剂量下显著降低。此外，剂量范围为5-100 μ g的TAM完全防止了SUL诱导的BW增加和摄食过多。BR也可防止SUL对BW和FI的影响。与BR相反，TAM的伴随给药不能预防SU L诱导的高泌乳素血症。单独使用SUL或SUL加BR均未改变雌二醇水平，但在TAM加SUL治疗的动物中，雌二醇水平显著升高。抗精神病药诱导的雌性大鼠肥胖可能与继发于高催乳素血症的性腺类固醇平衡改变有关。BR可能通过预防高泌乳素血症来抵消抗精神病药诱导的体重增加，而TAM可能直接与雌激素受体相互作用，或间接增加雌二醇水平。TAM在预防抗精神病药诱导的人类肥胖中的应用值得进一步研究。(C)1997年爱思唯尔科学公司
To evaluate its potential utility in counteracting neuroleptic-induced obesity, the effects of long-term administration of tamoxifen (TAM) on body weight (BW) and food intake (FI) of gonadalIy intact and sulpiride-treated (SUL) female rats were assessed. In addition, estradiol and prolactin serum levels were measured in rats treated with SUL, SUL plus TAM and SUL plus bromocriptine (BR). TAM, at doses of 10, 50 and 100 pg, significantly decreased BW gain; FI was significantly reduced at the doses of 50 and 100 mu g. In addition, doses of TAM ranging from 5-100 mu g completely prevented SUL-induced BW gain and hyperphagia. BR also prevented SUL effects on BW and FI. In contrast to BR, concomitant administration of TAM did not prevent SUL-induced hyperprolactinemia. Estradiol levels were not modified by SUL alone or SUL plus BR, but they were significantly increased in the animals treated with TAM plus SUL. Neuroleptic-induced obesity in female rats might be related to an alteration in gonadal steroid balance secondary to hyperprolactinemia. While BR might counteract neuroleptic-induced weight gain by preventing hyperprolactinemia, TAM might directly interact with estrogen receptors, or indirectly increase estradiol levels. The use of TAM in preventing neuroleptic-induced obesity in humans warrants further investigation. (C) 1997 Elsevier Science Inc.