Three new isobenzofurans from Lavandula angustifolia and their bioactivities
Three new isobenzofurans from Lavandula angustifolia and their bioactivities
复制标题
薰衣草中三种新的异苯并呋喃及其生物活性
作者：
Min Zhou;Huan-Huan Xing;Hang-Ying Ma;Lin Zhou;Yan Yang;Gan-Peng Li;Wei-Yao Hu;Qiang Liu;Xue-Mei Li;Qiu-Fen Hu
从狭叶熏衣草（Lavandula angustifolia）全草中分离出三个新的异苯并呋喃类化合物，即熏衣草内酯A-C（1-3），以及三个已知化合物（4-6）。它们的结构是根据详细的光谱分析（1D-和2D-NMR，HRESIMS，UV和IR）和与文献报道的数据比较确定的。对新分离物进行了抗烟草花叶病毒（TMV）活性和细胞毒活性测定。结果表明，化合物1-3具有较强的抗TMV活性，抑制率分别为31.8%、29.6%和33.4%。这些比率高于阳性对照。化合物1-3还显示出对一些测试的人肿瘤细胞系的弱抑制活性，IC 50值在1.5至5.7mM范围内。
Three new isobenzofurans, lavandulactones A–C (1–3), together with three known ones (4–6), were.isolated from the whole herb of Lavandula angustifolia. Their structures were established on the basis of.detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data.reported in the literature. New isolates were evaluated for their anti-tobacco mosaic virus (TMV).activities and cytotoxicity activities. The results revealed that compounds 1–3 showed high anti-TMV.activity with inhibition rate of 31.8, 29.6 and 33.4%, respectively. These rates are higher than that of.positive control. Compounds 1–3 also showed weak inhibitory activities against some tested human.tumor cell lines with IC50 values ranging from 1.5 to 5.7 mM.