The estimation of mutation rates when premeiotic events are involved.
The estimation of mutation rates when premeiotic events are involved.
复制标题
当涉及减数分裂前事件时突变率的估计。
DOI：
10.1002/em.2860010110
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
W. Engels
中科院分区：
文献类型：
--
作者：
W. Engels
当突变或重组事件在减数分裂前发生时，后代中例外个体的分布将是“聚集”的，而不是二项分布。即使聚类的确切性质通常是未知的，无偏的方法来测量突变率，并确定这些测量的精度，以取代现在经常使用的有偏的方法。当聚类是明显的，未加权的平均突变率被发现是一个更有效的估计比通常的平均家庭规模加权。本文还讨论了在缺乏聚类机制的具体知识的情况下统计推断和最优实验设计的方法。
When mutation or recombination events occur premeiotically, the distribution of exceptional individuals among the offspring will be "clustered" as opposed to binomial. Even though the exact nature of the clustering is usually unknown, unbiased methods for measuring mutation rate and determining the precision of these measurements are given to replace a biased method now frequently used. When clustering is pronounced, the unweighted average mutation rate is found to be a more efficient estimator than the usual average weighted by family size. Methods of statistical inference and optimal experimental design in the absence of specific knowledge of the mechanism of clustering are also discussed.