Esophageal Stem Cells-A Review of Their Identification and Characterization
Esophageal Stem Cells-A Review of Their Identification and Characterization
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DOI：
10.1007/s12015-008-9031-3
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发表时间：
2008-12-01
期刊：
影响因子：
--
通讯作者：
Kaur, Pritinder
中科院分区：
文献类型：
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作者：
Croagh, Daniel;Thomas, Robert J. S.;Kaur, Pritinder
在过去的40年里，食管腺癌的发病率比任何其他内部恶性肿瘤都增长得快。尽管如此，令人惊讶的是，很少有人知道这种组织的基本生物学，特别是关于上皮内细胞增殖的组织。这对于我们理解食管癌的发病机制至关重要。然而，近年来，在小鼠和人食管干细胞及其后代的鉴定和功能表征方面取得了重大进展。这使研究人员处于一个令人兴奋的位置，一方面可以进一步了解组织更新和修复的过程，另一方面可以了解发育异常和恶性肿瘤的发展。
The incidence of adenocarcinoma of the esophagus has increased faster than any other internal malignancy over the last 40 years. Despite this, surprisingly little is known about the basic biology of this tissue, particularly with regards to the organization of cell proliferation within the epithelium. This is a matter of crucial importance for our understanding of the pathogenesis of esophageal cancer. Nevertheless, significant advances have recently been made in the identification and functional characterization of both murine and human esophageal stem cells and their progeny in recent years. This places investigators in an exciting position to gain further insights into the processes of tissue renewal and repair on the one hand and the development of dysplasia and malignancy on the other.