Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer
Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer
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DOI：
10.1080/01635581.2015.1087042
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发表时间：
2015-11-17
影响因子：
2.9
通讯作者：
Ameen, Syeda Sadia
中科院分区：
文献类型：
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作者：
Bin Sayeed, Muhammad Shahdaat;Ameen, Syeda Sadia
目前所有可用的癌症治疗方案都很昂贵，但没有一种是安全的。然而，传统的植物衍生药物或化合物相对安全。一种广为人知的此类化合物是β-谷甾醇（BS），其是一种植物来源的营养物，具有针对乳腺癌、前列腺癌、结肠癌、肺癌、胃癌、卵巢癌和白血病的抗癌特性。研究表明，BS干扰多种细胞信号通路，包括细胞周期、凋亡、增殖、存活、侵袭、血管生成、转移和炎症。大多数研究都是不完整的，部分原因是BS的效力相对较低。但事实上，它通常被认为是无毒的，与目前所有可用的癌症化学疗法相反，几乎所有的研究团体都没有发现。为了抵消BS的低功效，设计用于癌细胞特异性治疗的BS递送具有巨大的潜力。通过脂质体递送BS是已经显示出非常有前途的此类示范之一。但是，进一步的研究既没有在BS的药物递送领域，也没有在如何提高BS介导的抗癌活性的领域取得进展，从而使BS成为孤儿营养品。因此，强烈建议将BS作为有效的抗癌营养品进行广泛的研究。
All the currently available cancer therapeutic options are expensive but none of them are safe. However, traditional plant-derived medicines or compounds are relatively safe. One widely known such compound is beta-sitosterol (BS), a plant derived nutrient with anticancer properties against breast cancer, prostate cancer, colon cancer, lung cancer, stomach cancer, ovarian cancer, and leukemia. Studies have shown that BS interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation. Most of the studies are incomplete partly due to the fact that BS is relatively less potent. But the fact that it is generally considered as nontoxic, the opposite of all currently available cancer chemo-therapeutics, is missed by almost all research communities. To offset the lower efficacy of BS, designing BS delivery for cancer cell specific therapy hold huge potential. Delivery of BS through liposome is one of such demonstrations that has shown to be highly promising. But further research did not progress neither in the field of drug delivery of BS nor in the field on how BS mediated anticancer activities could be improved, thus making BS an orphan nutraceutical. Therefore, extensive research with BS as potent anticancer nutraceutical is highly recommended.