Atypical expansion in mice of the sensory neuronspecific Mrg G protein-coupled receptor family
Atypical expansion in mice of the sensory neuronspecific Mrg G protein-coupled receptor family
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DOI：
10.1073/pnas.1732949100
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发表时间：
2003-08-19
影响因子：
11.1
通讯作者：
Anderson, DJ
中科院分区：
文献类型：
--
作者：
Zylka, MJ;Dong, XZ;Anderson, DJ
Mas相关基因（Mrgs）包括一个>50个G蛋白偶联受体（GPCR）家族，其中许多在小鼠中的伤害感受性感觉神经元的特定亚群中表达。相比之下，人类包含一个相关但非直系的基因家族，称为MrgX或感觉神经元特异性受体，其中很少出现在感觉神经元中表达。为了确定是否是通用的啮齿类动物或小鼠的非典型特征的小鼠Mrgs的多样性，我们的特点MrgrA，MrgB，MrgC和MrgD亚家族在大鼠和沙鼠。令人惊讶的是，虽然小鼠有大约22个MrgA和大约14个MrgC基因，但大鼠和沙鼠只有一个MrgA和MrgC基因。这种鼠特异性扩增可能反映了最近逆转录转座子介导的不平等交换事件。Mrgs在大鼠感觉神经节中的表达表明，小鼠中广泛的细胞多样性可以简化为大约四种不同基因（MrgA，MrgB，MrgC和MrgD）的核心子集，定义了类似数量的神经元亚群。我们的研究结果更普遍地表明，小鼠-人类基因组比较有时可能揭示啮齿动物的非典型差异。
The Mas-related genes (Mrgs) comprise a family of >50 G protein-coupled receptors (GPCRs), many of which are expressed in specific subsets of nociceptive sensory neurons in mice. In contrast, humans contain a related but nonorthologous family of genes, called MrgXs or sensory neuron-specific receptors, of which many fewer appear to be expressed in sensory neurons. To determine whether the diversity of murine Mrgs is generic to rodents or is an atypical feature of mice, we characterized MrgrA, MrgB, MrgC, and MrgD subfamilies in rat and gerbil. Surprisingly, although mice have approximate to22 MrgA and approximate to14 MrgC genes, rats and gerbils have just a single MrgA and MrgC gene. This murine-specific expansion likely reflects recent retrotransposon-mediated unequal crossover events. The expression of Mrgs in rat sensory ganglia suggests that the extensive cellular diversity in mice can be simplified to a core subset of approximately four different genes (MrgA, MrgB, MrgC, and MrgD), defining a similar number of neuronal subpopulations. Our results suggest more generally that mouse-human genomic comparisons may sometimes reveal differences atypical of rodents.