Assessment of Pulmonary Toxicity of MgO Nanoparticles in Rats
Assessment of Pulmonary Toxicity of MgO Nanoparticles in Rats
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DOI：
10.1002/tox.21908
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发表时间：
2015-03-01
影响因子：
4.5
通讯作者：
Anreddy, Rama Narsimha Reddy
中科院分区：
文献类型：
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作者：
Gelli, Kiranmai;Porika, Mahendar;Anreddy, Rama Narsimha Reddy
在这项研究中，我们评估了大鼠接触氧化镁纳米粒子（MgO NPs）后的肺毒性。磷酸盐缓冲盐水 + 1% Tween 80 中的 NP 通过气管内滴注以 1 mg/kg 或 5 mg/kg 的剂量暴露到大鼠肺部，并评估支气管肺泡灌洗 (BAL) 液中的各种组织损伤标志物，如碱性磷酸酶 (ALP) 和乳酸脱氢酶 (LDH)，以及在治疗后 1、7 和 30 天的肺部组织病理学。曝光后间隔。在所有暴露后阶段，与假手术对照相比，在大鼠肺 BAL 液体中观察到 ALP 和 LDH 活性呈剂量依赖性增加（P
In this study, we have evaluated the pulmonary toxicity of MgO nanoparticles (MgO NPs) in rats following their exposure. NPs in phosphate buffered saline + 1% Tween 80 were exposed via intratracheal instillation at a doses of 1 mg/kg or 5 mg/kg into rat lungs and evaluated for various tissue damage markers like alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid and histopathology of lungs at 1, 7, and 30 days of post-exposure intervals. A dose-dependant increase in ALP and LDH activity was observed in BAL fluids of rat lungs than sham control at all post-exposure periods (P