Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark
Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark
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DOI：
10.1136/oemed-2018-105469
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发表时间：
2019-04-01
影响因子：
4.9
通讯作者：
Weisskopf, Marc G.
中科院分区：
文献类型：
--
作者：
Dickerson, Aisha S.;Hansen, Johnni;Weisskopf, Marc G.
先前的研究表明，铅暴露与神经退行性疾病（包括肌萎缩性侧索硬化症（ALS））风险增加之间存在联系。在本研究中，我们评估了职业铅暴露与ALS之间的关系。方法通过1982 - 2013年丹麦国家患者登记处确定AL - S病例，年龄和性别与100例对照相匹配。利用1964年以来丹麦养老基金的完整就业历史，通过丹麦工作暴露矩阵估计每个受试者的累积铅暴露。使用条件逻辑回归分析评估关联，并按性别分层。对于暴露概率为50%的男性，在诊断前5年（aOR: 1.35; 95% CI 1.04至1.76）和诊断前10年（aOR: 1.33; 95% CI 1.03至1.72）的任何时间，暴露在第60百分位或更高的男性患ALS的几率增加。在女性中没有观察到显著的关联，并且没有发现任何性别的铅暴露的线性趋势。结论我们的研究表明持续较高的职业铅暴露与ALS之间存在关联。这些发现支持了先前报道的ALS与通常经历铅暴露的特定职业之间的关联。
Objectives Previous research has indicated links between lead (Pb) exposure and increased risk of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In this study, we evaluated the association between occupational Pb exposures and ALS. Methods AL S cases were ascertained through the Danish National Patient Registry from 1982 to 2013 and age and sex-matched to 100 controls. Using complete employment history since 1964 from the Danish Pension Fund, cumulative Pb exposure was estimated for each subject via a Danish job exposure matrix. Associations were evaluated using conditional logistic regression analyses and stratified by sex. Results For men with > 50% probability of exposure, there was an increase in odds of ALS for exposures in the 60th percentile or higher during any time 5 years prior to diagnosis (aOR: 1.35; 95% CI 1.04 to 1.76) and 10 years prior to diagnosis (aOR: 1.33; 95% CI 1.03 to 1.72). No significant associations were observed in women, and there were no linear trends seen for Pb exposures for either sex. Conclusions Our study indicates an association between consistently higher occupational Pb exposures and ALS. These findings support those of previously reported associations between ALS and specific occupations that commonly experience Pb exposure.