Physical activity and health-related quality of life in young adult cancer survivors: a Canadian provincial survey
Physical activity and health-related quality of life in young adult cancer survivors: a Canadian provincial survey
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DOI：
10.1007/s11764-010-0146-6
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发表时间：
2011-03-01
影响因子：
3.7
通讯作者：
Courneya, Kerry S.
中科院分区：
文献类型：
--
作者：
Belanger, Lisa J.;Plotnikoff, Ronald C.;Courneya, Kerry S.
目的体力活动(PA)可改善癌症存活者群体中与健康相关的生活质量(HRQL)，但尚未有针对年轻成年癌症存活者(YAC)的研究。本研究确定了PA在YACS中的患病率，并检查了与HRQL的剂量-反应关系。方法随机抽取2,000名年龄在20-44岁之间的YAC，通过加拿大省级癌症登记中心进行鉴定，并邮寄一份调查问卷，其中包括休闲时间锻炼问卷、医学结果研究36项简表(SF36)调查，以及几个有效的心理社会量表。主要终点为SF36的物理成分概要(PCS)。结果共收到588份YAC问卷。在PA流行方面，23%的人完全久坐不动，25%的人活动不足，22%的人在公共卫生指南范围内活动，29%的人在公共卫生指南上活动。对重要的医学和人口统计协变量进行的协方差分析表明，PA和PCS之间的剂量-反应关系具有统计学意义和临床意义，从完全久坐到指南范围内的范围为6.3点(95%可信区间[CI]3.7至8.8；p<；0.001)。心理成分总结量表(p=0.002)、抑郁(p<；0.001)、压力(p<；0.001)和自尊(p<；0.001)也有类似的关联。在接受过化疗的YACS患者中，PA与HRQL之间的相关性更强。结论PA与YACS患者的HRQL密切相关，但只有一半的YACS患者符合公共卫生指南，近四分之一的患者完全久坐不动。在这一研究不足的患者群体中，有必要进行随机对照试验，检查增加PA和改善健康结局的干预策略。
Objectives Physical activity (PA) improves health-related quality of life (HRQL) in several cancer survivor groups but no studies have focused on young adult cancer survivors (YACS). This study determined the prevalence of PA in YACS and examined dose-response associations with HRQL.Methods A random sample of 2,000 YACS between the ages of 20-44 were identified through a Canadian provincial cancer registry and mailed a survey that included the Leisure-Time Exercise Questionnaire, the Medical Outcomes Study 36-Item Short Form (SF36) survey, and several validated psychosocial scales. The primary endpoint was the physical component summary (PCS) of the SF36.Results Completed questionnaires were received from 588 YACS. In terms of PA prevalence, 23% were completely sedentary, 25% were insufficiently active, 22% were active within public health guidelines, and 29% were active above public health guidelines. Analysis of covariance adjusted for important medical and demographic covariates showed a statistically significant and clinically meaningful dose-response association between PA and the PCS that spanned 6.3 points (95% confidence interval [CI] 3.7 to 8.8; p < 0.001) from completely sedentary to within guidelines. Similar associations were found for the mental component summary scale (p = 0.002), depression (p < 0.001), stress (p < 0.001) and self-esteem (p < 0.001). Associations between PA and HRQL were stronger for YACS that had previously received chemotherapy.Conclusions PA is strongly associated with HRQL in YACS but only half of YACS are meeting public health guidelines and almost a quarter are completely sedentary. Randomized controlled trials examining intervention strategies to increase PA and improve health outcomes in this understudied patient population are warranted.