Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells.
Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells.
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DOI：
10.1186/s41021-016-0051-y
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Kamiya H
中科院分区：
文献类型：
--
作者：
Suzuki T;Kamiya H
鸟嘌呤氧化发生在 DNA 和细胞核苷酸池中，主要产物之一是 8-羟基鸟嘌呤（8-氧代-7,8-二氢鸟嘌呤）。已在各种实验系统中检查了这种氧化碱的诱变潜力。在这篇综述中，我们总结了哺乳动物细胞中碱基的致突变性。我们还描述了专门的 DNA 聚合酶、DNA 修复蛋白和核苷酸池消毒酶的作用。
Guanine oxidation occurs in both DNA and the cellular nucleotide pool, and one of the major products is 8-hydroxyguanine (8-oxo-7,8-dihydroguanine). The mutagenic potentials of this oxidized base have been examined in various experimental systems. In this review, we summarize the mutagenicity of the base in mammalian cells. We also describe the effects of specialized DNA polymerases, DNA repair proteins, and nucleotide pool sanitization enzymes.