Acute phase proteins in milk in naturally acquired bovine mastitis caused by different pathogens
Acute phase proteins in milk in naturally acquired bovine mastitis caused by different pathogens
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不同病原体引起的自然获得性牛乳腺炎牛奶中的急性期蛋白
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
T. Orro
中科院分区：
文献类型：
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作者：
S. Pyörälä;M. Hovinen;H. Simojoki;J. Fitzpatrick;P. D. Eckersall;T. Orro
检测了234头不同病原体引起的自发性乳房炎奶牛的乳汁中结合珠蛋白（Hp）、血清淀粉样蛋白A（SAA）浓度和N-乙酰-β-D-氨基葡萄糖苷酶（NAGase）活性，以评价其是否与乳房炎的临床症状相对应以及病原体之间是否存在差异。98头奶牛患有临床型乳房炎，136头患有亚临床型乳房炎。SAA和Hp浓度与NAGase活性呈显著正相关。不同病原体引起的乳房炎奶牛的乳汁中急性时相蛋白浓度和NAGase活性存在显著差异。最高浓度的Hp和NAGase被发现在由大肠杆菌和化脓隐秘杆菌引起的乳腺炎的情况下，和最低浓度的凝固酶阴性葡萄球菌引起的乳腺炎的情况下。与其他主要乳腺炎病原体引起的病例相比，化脓性放线菌引起的病例的乳汁中SAA浓度非常低。在大肠杆菌引起的乳腺炎病例中，SAA的中位浓度比其他病原体引起的乳腺炎高10倍以上。临床型和亚临床型乳腺炎的平均Hp浓度和NAGase活性存在显著差异。在大约三分之一的样本中，Hp浓度低于检测限，可能会影响Hp作为乳腺炎标志物的使用。
The concentrations of haptoglobin (Hp) and serum amyloid A (SAA) and the activity of N-acetyl-β-D-glucosaminidase (NAGase) in milk from 234 cows with spontaneous mastitis caused by different pathogens were measured to assess whether they corresponded with the clinical signs of mastitis and whether there were any differences between pathogens. Ninety-eight of the cows had clinical mastitis and 136 had subclinical mastitis. There were statistically significant positive correlations between the concentrations of SAA and Hp and the activity of NAGase. Significant differences in the concentrations of acute phase proteins and NAGase activity were found in milk from cows with mastitis caused by different pathogens. The highest concentrations of Hp and NAGase were found in cases of mastitis caused by Escherichia coli and Arcanobacterium pyogenes, and the lowest concentrations were from cases of mastitis caused by coagulase-negative staphylococci. Very low SAA concentrations were found in milk from the cases caused by A pyogenes, in contrast to cases caused by other major mastitis pathogens. The median concentration of SAA was over 10 times higher in cases of mastitis caused by E coli than in mastitis caused by other pathogens. There were significant differences in the mean Hp concentration and NAGase activity between clinical and subclinical mastitis. In approximately one-third of the samples, the Hp concentration was below the detection limit, potentially compromising the use of Hp as a mastitis marker.
影响因子：
56.9
作者：
SCHUMANN, RR;LEONG, SR;ULEVITCH, RJ
通讯作者：
ULEVITCH, RJ