EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment.
EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment.
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DOI：
10.1016/b978-0-12-385855-9.00007-2
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发表时间：
2011
影响因子：
--
通讯作者：
Dou QP
中科院分区：
文献类型：
--
作者：
Chen D;Wan SB;Yang H;Yuan J;Chan TH;Dou QP
流行病学、临床前和临床研究已证明茶多酚，尤其是表没食子儿茶素 - 3 - 没食子酸酯（EGCG）具有预防癌症的作用。像EGCG这样的绿茶茶多酚有可能影响多种生物学途径，包括基因表达、生长因子介导的途径、丝裂原活化蛋白激酶依赖性途径以及泛素/蛋白酶体降解途径。因此，确定EGCG的分子靶点应极大地促进对其抗癌和预防癌症活性背后机制的更好理解。进行构效关系（SAR）研究也可极大地促进新型茶多酚类似物作为潜在抗癌和预防癌症药物的发现。在本章中，我们回顾了相关文献，这些文献涉及天然和合成绿茶茶多酚以及EGCG类似物对人类癌细胞的影响、它们潜在的分子靶点以及它们的抗肿瘤作用。我们还讨论了绿茶茶多酚在癌症预防中的意义。
Cancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG), have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea polyphenols such as EGCG have the potential to affect multiple biological pathways, including gene expression, growth factor-mediated pathways, the mitogen-activated protein kinase-dependent pathway, and the ubiquitin/proteasome degradation pathway. Therefore, identification of the molecular targets of EGCG should greatly facilitate a better understanding of the mechanisms underlying its anticancer and cancer-preventive activities. Performing structure–activity relationship (SAR) studies could also greatly enhance the discovery of novel tea polyphenol analogs as potential anticancer and cancer-preventive agents. In this chapter, we review the relevant literature as it relates to the effects of natural and synthetic green tea polyphenols and EGCG analogs on human cancer cells and their potential molecular targets as well as their antitumor effects. We also discuss the implications of green tea polyphenols in cancer prevention.
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影响因子：
4.2
作者：
Hakim, IA;Harris, RB;Talbot, W
通讯作者：
Talbot, W
影响因子：
3.3
作者：
Ho, Yung-Chuan;Yang, Shun-Fa;Chang, Yu-Chao
通讯作者：
Chang, Yu-Chao
影响因子：
4.2
作者：
Gu, Bin;Ding, Qiang;Fang, Zujun
通讯作者：
Fang, Zujun
影响因子：
6.1
作者：
Cheng, Chieh-Wen;Shieh, Po-Chuen;Way, Tzong-Der
通讯作者：
Way, Tzong-Der
影响因子：
12.4
作者：
An, B;Goldfarb, RH;Dou, QP
通讯作者：
Dou, QP