ABNORMAL INFLUENCES OF PASSIVE LIMB MOVEMENT ON THE ACTIVITY OF GLOBUS PALLIDUS NEURONS IN PARKINSONIAN MONKEYS
ABNORMAL INFLUENCES OF PASSIVE LIMB MOVEMENT ON THE ACTIVITY OF GLOBUS PALLIDUS NEURONS IN PARKINSONIAN MONKEYS
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DOI：
10.1016/0006-8993(88)90924-9
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发表时间：
1988-03-15
期刊：
影响因子：
2.9
通讯作者：
BEDARD, PJ
中科院分区：
文献类型：
--
作者：
FILION, M;TREMBLAY, L;BEDARD, PJ
记录了清醒食蟹猴被动肢体运动时苍白球细胞外单个单位的活动。主要的上肢和下肢关节进行了双边调查。这些动物要么是完整的，要么是被神经毒素1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）引起的帕金森病。细胞计数显示，在帕金森病动物中，至少90%的黑质神经元退化。在完整的动物中，只有17%的苍白球神经元对自然刺激有反应。正如其他人已经报道的那样，这些反应通常与单个对侧关节的运动有关，并且只在一个方向上。然而，在帕金森病动物中，更多的神经元对同样的刺激做出反应，而且往往更强烈。在许多这些神经元的反应引起的运动超过一个关节的上肢和下肢或同侧和对侧和在一个以上的方向。反应的数量和幅度的增加以及特异性的丧失在苍白球内侧段中要大得多，其中反应神经元的数量增加了四倍。这些结果表明，多巴胺能机制调节增益和选择性基底神经节。在多巴胺能功能下降的动物中，过度和非选择性的运动反应可以解释帕金森综合征的所有3个主要体征：强直、震颤和运动不能。
Extracellular single unit activity was recorded in the globus pallidus of waking Macaca fascicularis during passive limb movement. The main upper and lower limb joints were investigated bilaterally. The animals were either intact or rendered parkinsonian by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Cell counts showed that at least 90% of nigral neurons of the compacta-type were degenerated in the parkinsonian animals. In the intact animals, only 17% of the pallidal neurons responded to the natural stimulus. As already reported by others, the responses were typically related to movement about a single contralateral joint and in only one direction. In the parkinsonian animals, however, more neurons responded, often more vigorously, to the same stimulation. In many of these neurons the responses were elicited by movement about more than one joint of both upper and lower limbs or ipsi-and contralateral sides and in more than one direction. The increase in number and magnitude and loss of specificity of responses were much greater in the internal pallidal segment, where the number of responding neurons quadrupled. These results suggest that dopaminergic mechanisms regulate gain and selectivity in the basal ganglia. In animals with decreased dopaminergic functions, the excessive and unselective motor responses may explain all 3 major signs of parkinsonism: rigidity, tremor and akinesia.