Motion corrected free-breathing Delayed-enhancement imaging of myocardial infarction using nonrigid registration
Motion corrected free-breathing Delayed-enhancement imaging of myocardial infarction using nonrigid registration
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DOI：
10.1002/jmri.20957
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发表时间：
2007-07-01
影响因子：
4.4
通讯作者：
McVeigh, Elliot R.
中科院分区：
文献类型：
--
作者：
Ledesma-Carbayo, Maria J.;Kellman, Peter;McVeigh, Elliot R.
目的：开发和测试一种自动自由呼吸延迟增强成像方法，提高图像信噪比（SNR）。材料与方法：该方法使用自由呼吸，反转恢复单次快速成像与稳定进动（FISP）延迟增强与呼吸运动补偿的基础上非刚性图像配准。运动校正平均用于增强SNR。结果：将全自动非刚性配准与之前确认的需要用户交互的刚性配准进行了比较。通过心肌梗死（MI）增强区和右心室（RV）壁的强度分布中边缘位置的方差来测量性能。刚性体和非刚性配准的MI边缘测量变异分别为1.16 +/- 0.71 mm（N = 6例患者;平均值+/- SD）和1.08 +/- 0.76 mm（无显著差异）。另一方面，在RV边缘的测量中发现了显著改善（P < 0.005），其中刚性体的SD为2.06 +/- 0.56 mm，非刚性配准的SD为0.59 +/- 0.22 mm。结论：所提出的方法实现了延迟增强图像的高分辨率和SNR，而不需要屏住呼吸。使用非刚性图像配准的自由呼吸延迟增强成像的运动校正可以以全自动的方式实现，并且在整个视场（FOV）上均匀地良好地执行。
Purpose: To develop and test an automatic free-breathing, delayed enhancement imaging method with improved image signal-to-noise ratio (SNR). Materials and Methods: The proposed approach uses free-breathing, inversion-recovery single-shot fast imaging with steady precession (FISP) delayed-enhancement with respiratory motion compensation based on nonrigid image registration. Motion-corrected averaging is used to enhance SNR. Results: Fully automatic, nonrigid registration was compared to previously validated rigid body registration that required user interaction. The performance was measured using the variance of edge positions in intensity profiles through the myocardial infarction (MI) enhanced region and through the right ventricular (RV) wall. Measured variation of the MI edge was 1.16 +/- 0.71 mm (N = 6 patients; mean +/- SD) for rigid body and 1.08 +/- 0.76 mm for nonrigid registration (no significant difference). On the other hand, significant improvement (P < 0.005) was found in the measurements at the RV edge where the SD was 2.06 +/- 0.56 mm for rigid body and 0.59 +/- 0.22 mm for nonrigid registration. Conclusion: The proposed approach achieves delayed enhancement images with high resolution and SNR without requiring a breathhold. Motion correction of free-breathing delayed-enhancement imaging using nonrigid image registration may be implemented in a fully automatic fashion and performs uniformly well across the full field of view (FOV).