Impact of updated international diagnostic criteria for the diagnosis of polycystic ovary syndrome.
Impact of updated international diagnostic criteria for the diagnosis of polycystic ovary syndrome.
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DOI：
10.1016/j.xfre.2022.12.003
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发表时间：
2023-06
期刊：
影响因子：
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通讯作者：
Knudtson, Jennifer F
中科院分区：
文献类型：
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作者：
Kostroun, Katherine E;Goldrick, Kathryn;Mondshine, Jessica N;Robinson, Randal D;Mankus, Erin;Reddy, Srinidhi;Wang, Zhu;Song, Xuemei;Knudtson, Jennifer F
研究应用2018年新的多囊卵巢综合征（PCOS）诊断指南是否会降低PCOS的诊断率。其次，比较这个新定义中包含和排除的女性的代谢特征。回顾性横截面图表审查。大学附属医院系统。 12-50 岁的女性，2017 年国际疾病分类代码为“多囊卵巢综合征”。应用 2018 年新的 PCOS 诊断指南。主要结局是应用 2018 年新指南后保留 PCOS 诊断。次要结果包括代谢危险因素的比较。使用分类变量的卡方检验和连续变量的不配对 t 检验进行分析，P 值 <.05 确定为显着。根据鹿特丹标准，在 258 名患有 PCOS 的女性中，只有 195 名 (76%) 符合 2018 年新指南的标准。那些仅符合鹿特丹标准的女性 (n = 63) 的体重指数显着较低（32.7 vs. 35.8），总胆固醇水平较低（151 vs. 176 mg/dL），甘油三酯水平较低（96 vs. 124 mg/dL），总胆固醇水平较低（33.2 vs. 52.3 ng/dL）和游离睾酮水平（4.7 vs. 8.3），较低。与符合 2018 年标准的女性相比，抗苗勒氏管激素水平更高（3.1 与 7.7 ng/mL），并且多产的可能性更大（50% 与 29%）。将最小窦卵泡计数增加到 ≥20 个窦卵泡可显着减少诊断为 PCOS 的女性数量。此外，符合新标准的女性比仅符合鹿特丹标准的女性患代谢综合征的健康风险更大。
To study whether application of the new 2018 guidelines for the diagnosis of polycystic ovary syndrome (PCOS) would decrease the diagnosis of PCOS. Second, to compare the metabolic profiles of women included and excluded in this new definition. Retrospective cross-sectional chart review. University-affiliated hospital system. Women, ages 12–50, with the International Classification of Diseases code “Polycystic Ovary Syndrome” in 2017. Application of the new 2018 guidelines for the diagnosis of PCOS. The primary outcome was the retention of PCOS diagnosis after applying the new 2018 guidelines. Secondary outcomes included the comparison of metabolic risk factors. Analysis was performed using chi-square tests for categorical variables and unpaired t tests for continuous variables, with a P value of <.05 determined to be significant. Of 258 women with PCOS based on Rotterdam criteria, only 195 (76%) met the criteria based on the new 2018 guidelines. Those women who only met Rotterdam criteria (n = 63) had significantly lower body mass index (32.7 vs. 35.8), lower total cholesterol levels (151 vs. 176 mg/dL), lower triglyceride levels (96 vs. 124 mg/dL), lower total (33.2 vs. 52.3 ng/dL) and free testosterone levels (4.7 vs. 8.3), lower antimüllerian hormone levels (3.1 vs. 7.7 ng/mL), and were more likely to be multiparous (50% vs. 29%) than women who met 2018 criteria. Increasing the minimum antral follicle count to ≥20 antral follicles significantly decreases the number of women with the diagnosis of PCOS. Furthermore, the women that meet the new criteria have more health risks for metabolic syndrome than those who only meet the Rotterdam criteria.