Causal discovery replicates symptomatic and functional interrelations of posttraumatic stress across five patient populations.
Causal discovery replicates symptomatic and functional interrelations of posttraumatic stress across five patient populations.
复制标题
因果发现在五名患者人群中复制创伤后压力的症状和功能相互关系。
DOI：
10.3389/fpsyt.2022.1018111
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
Nielson, Jessica L.
中科院分区：
文献类型：
--
作者：
Pierce, Benjamin;Kirsh, Thomas;Ferguson, Adam R.;Neylan, Thomas C.;Ma, Sisi;Kummerfeld, Erich;Cohen, Beth E.;Nielson, Jessica L.
关键词：
大约一半的创伤后应激障碍（PTSD）患者可能符合其他精神疾病的标准，PTSD症状与健康和心理社会功能下降有关。然而，很少有研究探讨PTSD症状的纵向进展与相关的症状领域和功能的结果，这样可能会忽略重要的纵向模式的症状进展以外的PTSD具体。因此，我们使用纵向因果发现分析来检查PTSD症状，抑郁症状，药物滥用和五个纵向队列中的各种其他功能领域之间的纵向相互关系，这些纵向队列代表退伍军人（n = 241），寻求焦虑症治疗的平民（n = 79），寻求创伤后应激和药物滥用治疗的平民妇女（n = 116），现役军人在TBI后0-90天进行评估（n = 243），平民有TBI史（n = 43）。这些分析揭示了从PTSD症状到抑郁症状的一致的、直接的关联，物质使用问题的独立纵向轨迹，以及从PTSD症状到社会功能通过抑郁的级联间接关系，以及从PTSD症状到TBI结果的直接关系。我们的研究结果表明，随着时间的推移，PTSD症状主要驱动抑郁症状，往往表现出与物质使用症状的独立性，并可能级联为其他领域的损害。这些结果对PTSD共病的概念化有一定的意义，并可以为经历PTSD症状沿着共同发生的痛苦或损伤的个体的预后和治疗假设提供信息。
Approximately half of individuals with posttraumatic stress disorder (PTSD) may meet criteria for other psychiatric disorders, and PTSD symptoms are associated with diminished health and psychosocial functioning. However, few studies examine the longitudinal progression of PTSD symptoms concurrent with related symptom domains and functional outcomes, such that may neglect important longitudinal patterns of symptom progression beyond PTSD specifically. Therefore, we used longitudinal causal discovery analysis to examine the longitudinal interrelations among PTSD symptoms, depressive symptoms, substance abuse, and various other domains of functioning in five longitudinal cohorts representing veterans (n = 241), civilians seeking treatment for anxiety disorders (n = 79), civilian women seeking treatment for post-traumatic stress and substance abuse (n = 116), active duty military members assessed 0–90 days following TBI (n = 243), and civilians with a history of TBI (n = 43). The analyses revealed consistent, directed associations from PTSD symptoms to depressive symptoms, independent longitudinal trajectories of substance use problems, and cascading indirect relations from PTSD symptoms to social functioning through depression as well as direct relations from PTSD symptoms to TBI outcomes. Our findings suggest PTSD symptoms primarily drive depressive symptoms over time, tend to show independence from substance use symptoms, and may cascade into impairment in other domains. The results have implications for refining conceptualization of PTSD co-morbidity and can inform prognostic and treatment hypotheses about individuals experiencing PTSD symptoms along with co-occurring distress or impairment.
登录
查看更多内容
影响因子：
6.6
作者：
Elhai, Jon D.;Contractor, Ateka A.;Galea, Sandro
通讯作者：
Galea, Sandro
DOI：
10.1007/s10862-016-9555-9
发表时间：
2016-12-01
影响因子：
1.6
作者：
Byllesby, Brianna M.;Charak, Ruby;Elhai, Jon D.
通讯作者：
Elhai, Jon D.
影响因子：
3.1
作者：
Biehn, Tracey L.;Elhai, Jon D.;Forbes, David
通讯作者：
Forbes, David
洪水幸存者中创伤后应激障碍和焦虑的合并症：流行和共同的危险因素。
影响因子：
1.6
作者：
Dai W;Kaminga AC;Tan H;Wang J;Lai Z;Wu X;Xiong Y;Deng J;Liu A
通讯作者：
Liu A
影响因子：
3.3
作者：
Caramanica, Kimberly;Brackbill, Robert M.;Stellman, Steven D.
通讯作者：
Stellman, Steven D.