Carbonic anhydrase II autoantibody and oxidative stress in rheumatoid arthritis
Carbonic anhydrase II autoantibody and oxidative stress in rheumatoid arthritis
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DOI：
10.1016/j.clinbiochem.2011.09.014
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发表时间：
2011-12-01
影响因子：
2.8
通讯作者：
Ucar, Fahri
中科院分区：
文献类型：
--
作者：
Alver, Ahmet;Senturk, Ayse;Ucar, Fahri
目的：探讨类风湿关节炎(RA)患者血清中CA-II自身抗体与脂质过氧化、某些抗氧化剂参数及细胞因子的关系。设计与方法：检测类风湿关节炎(RA)患者血清中CA-II自身抗体、细胞因子(肿瘤坏死因子α、IL-6、干扰素-γ、IL-β)、骨标志物(Crosslaps、Osteocaline)水平及红细胞抗氧化酶活性(SOD、CAT、GPx)、谷胱甘肽(GSH)、丙二醛(MDA)水平及CA活性。结果：RA患者血清CA-II自身抗体滴度显著高于正常对照组(P
Objectives: To investigate the relationship between carbonic anhydrase (CA) II autoantibody and lipid peroxidation, certain antioxidant parameters, and cytokines in rheumatoid arthritis (RA) patients.Design and methods: Serum levels of CA II autoantibody, cytokines (TNF alpha, IL-6, IFN-gamma, IL-beta) and bone markers (crosslaps, osteocalcine) and erythrocyte levels of antioxidant enzyme activities (SOD, CAT, GPx), GSH and MDA, and CA activities were measured in RA patients and healthy controls.Results: The CA II autoantibody titers were significantly higher (P