Influence of light on growth, conidiation and the mutual regulation of fumonisin B2 and ochratoxin A biosynthesis by Aspergillus niger
Influence of light on growth, conidiation and the mutual regulation of fumonisin B2 and ochratoxin A biosynthesis by Aspergillus niger
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DOI：
10.3920/wmj2011.1364
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发表时间：
2012-05-01
影响因子：
2
通讯作者：
Mule, G.
中科院分区：
文献类型：
--
作者：
Fanelli, F.;Schmidt-Heydt, M.;Mule, G.
尼日尔是一种能够产生致癌真菌毒素赭曲霉毒素A（OTA）和伏马菌素的真菌。分析了不同波长的光对A.尼日尔项目7097.光谱两侧的光，从长波长（627 nm）到短波长（470-455 nm），对生长都有刺激作用，在蓝光（455 nm，1,700 Lux）和短波蓝光（390 nm）下刺激作用最大。在短的蓝色波长（455 nm，200 Lux）下，分生孢子减少40%，但在更短波长（390 nm）的光下强烈促进分生孢子形成，与黑暗相比增加约200倍。FB 2和OTA的产生受光的相互调节。在光条件下促进了FB 2的产生：红光和蓝光尤其使FB 2的生物合成增加了40%。相反，OTA生产大大抑制红光和蓝光下相比，黑暗孵育，平均减少约40倍，这表明两个生物合成途径的反向调节。在390 nm波长下孵育可将两种毒素的产生抑制至不可检测的水平。
Aspergillus niger is a fungus able to produce the carcinogenic mycotoxins ochratoxin A (OTA) and fumonisins. We analysed the influence of light of various wavelengths on growth, conidiation, fumonisin B-2 (FB2) and OTA biosynthesis by A. niger ITEM 7097. Light from both sides of the spectrum, from long (627 nm) to short wavelengths (470-455 nm), had a stimulating effect on growth, with the highest stimulation under blue (455 nm, 1,700 Lux) and short-wave blue light (390 nm). Conidiation was reduced by 40% under a short blue wavelength (455 nm, 200 Lux), but strongly promoted under light at an even shorter wavelength (390 nm), with an increase of about 200 fold in comparison to the dark. Production of FB2 and OTA was mutually regulated by light. FB2 production was promoted under light conditions: red and blue light in particular increased FB2 biosynthesis by 40%. Conversely, OTA production was greatly inhibited under red and blue light in comparison to dark incubation, with a mean reduction of about 40 fold, indicating a reverse regulation of both biosynthetic pathways. Incubation under a 390 nm wavelength repressed the production of both toxins to non-detectable levels.