Osteogenecity of octacalcium phosphate coatings applied on porous metal implants
Osteogenecity of octacalcium phosphate coatings applied on porous metal implants
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DOI：
10.1002/jbm.a.10454
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发表时间：
2003-09-15
影响因子：
4.9
通讯作者：
Layrolle, P
中科院分区：
文献类型：
--
作者：
Barrère, F;van der Valk, CM;Layrolle, P
这种仿生方法可以通过浸泡在模拟生理溶液中，在多孔植入物上均匀沉积钙磷涂层。此外，还可以沉积各种钙磷相，如只有在低温下才稳定的磷酸八钙(OCP)或类骨碳化磷灰石(BCA)。在这项初步研究中，实验设计有两个目的：(1)研究OCP涂层和非涂层多孔钽柱体以及致密钛合金柱体(直径5 mm，长10 mm)在12周和24周山羊背部肌肉中的成骨诱导作用(n=4)；以及(2)比较BCA涂层、OCP涂层和裸露的多孔钽柱体在12周时在山羊股骨髁处形成的1 mm间隙中的成骨潜能(n=2)。在山羊肌肉中，12周后，OCP涂层的多孔圆柱体已经诱导出异位骨，并且在OCP涂层的致密钛圆柱体的腔内也有骨形成。在股骨髁，骨没有填补任何多孔植入物的缺口。与其他两组相比，OCP涂层的多孔圆柱体在植入物的中心显示出骨形成。钙磷涂层的性质，通过其微观结构、溶解速度和与体液的特殊相互作用，可能会影响钙磷生物材料的成骨能力。(C)2003年威利期刊公司。
The biomimetic route allows the homogeneous deposition of calcium phosphate (Ca-P) coatings on porous implants by immersion in simulated physiologic solution. In addition, various Ca-P phases, such as octacalcium phosphate (OCP) or bone-like carbonated apatite (BCA), which are stable only at low temperatures, can be deposited. In this pilot study, experiments were designed with a twofold-purpose: (1) to investigate the osteoinduction of OCP-coated and noncoated porous tantalum cylinders and of dense titanium alloy cylinders (5 mm in diameter and 10 mm in length) in the back muscle of goats at 12 and 24 weeks (n = 4); and (2) to compare the osteogenic potentials of BCA-coated, OCP-coated, and bare porous tantalum cylinders in a gap of 1 mm created in the femoral condyle of a goat at 12 weeks (n = 2). In the goat muscle, after 12 weeks the OCP-coated porous cylinder had induced ectopic bone as well as bone within the cavity of the OCP-coated dense titanium cylinder. In the femoral condyle, bone did not fill the gap in any of the porous implants. In contrast with the two other groups, OCP-coated porous cylinders exhibited bone formation in the center of the implant. The nature of the Ca-P coating, via its microstructure, its dissolution rate, and its specific interactions with body fluids, may influence the osteogenecity of the Ca-P biomaterial. (C) 2003 Wiley Periodicals, Inc.