EPSTEIN-BARR VIRUS-INDUCED CELL-FUSION
EPSTEIN-BARR VIRUS-INDUCED CELL-FUSION
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DOI：
10.1038/287164a0
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发表时间：
1980-01-01
期刊：
影响因子：
64.8
通讯作者：
WOLF, H
中科院分区：
文献类型：
--
作者：
BAYLISS, GJ;WOLF, H
血清学和分子生物学研究1-3表明EB病毒(EBV)与鼻咽癌有关。尽管已证明上皮样肿瘤细胞携带EBV基因，但它们显然缺乏EBV受体(H.W.，未发表的观察结果)。其他人提出，携带EBV的细胞与上皮细胞的融合可能是病毒进入无法吸收病毒的细胞的方式，这可能是由居住在呼吸道的一种已知的合胞体形成病毒(例如，副粘病毒组的成员)介导的，De Thé和他的同事提出，在鼻咽癌肿瘤材料中可以看到细胞间的桥梁。我们已经开发了一种技术，可以制备稳定的人类淋巴母细胞系6。使用这项技术，我们现在已经证明，EBV可以诱导EBV重叠感染的淋巴母细胞和缺乏EBV受体的细胞之间的融合。
Serological and molecular biological studies1–3have shown an association between Epstein–Barr virus (EBV) and naso-pharyngeal carcinoma. Although it has been shown that the epithelioid tumour cells carry EBV genomes4, they are apparently devoid of receptors for EBV (H.W., unpublished observations). Others have suggested that fusion of EBV carrying cells with epithelial cells may be the mode of entry of the virus into cells unable to absorb the virus and that this may be mediated by one of the known syncytium-forming viruses which inhabit the respiratory tract (for example, members of the paramyxovirus group), de Thé and colleagues suggested that intercellular bridges could be seen in NPC tumour material5. We have developed a technique which permits the preparation of stable monolayers of viable human lymphoblastoid cell lines6. Using this technique we have now demonstrated that EBV can induce fusion between EBV-superinfected lymphoblastoid cells and cells devoid of EBV receptors.