Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol.
Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol.
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DOI：
10.1056/nejm198304143081502
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发表时间：
1983-04
期刊：
影响因子：
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通讯作者：
P. Wahl;C. Walden;R. Knopp;J. Hoover;Robert B. Wallace;Gerardo Heiss;B. Rifkind
中科院分区：
文献类型：
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作者：
P. Wahl;C. Walden;R. Knopp;J. Hoover;Robert B. Wallace;Gerardo Heiss;B. Rifkind
我们研究了374名服用口服避孕药的女性、284名绝经后服用雌激素制剂的女性和1086名未服用激素的女性，以确定血浆脂质和脂蛋白胆固醇浓度与各种类型的雌激素/孕激素制剂的关系。绝经前妇女，使用含有相对低剂量雌激素的口服避孕药结合中等或高剂量的孕酮（Norlestrin，Ovral或Demulen），其低密度脂蛋白胆固醇的中位数浓度比未使用激素的妇女高24%（P <0.05）。使用高雌激素低孕酮口服避孕药（Enovid或Oracon）的妇女，其高密度脂蛋白胆固醇浓度明显高于不使用者;使用Ovral（一种低雌激素高孕酮配方）的妇女，其高密度脂蛋白胆固醇水平明显较低。在绝经后妇女中，雌激素的使用与低密度脂蛋白胆固醇的浓度有关，低密度脂蛋白胆固醇的浓度比未使用激素的绝经后妇女低11%至19%。雌激素-孕酮平衡对低密度和高密度脂蛋白的影响可能是服用口服避孕药的育龄妇女中风和心肌梗死发病率增加的基础。
We studied 374 women taking oral contraceptives, 284 women taking estrogen preparations after menopause, and 1086 women taking no hormones, to determine the relation of plasma lipids and lipoprotein cholesterol concentrations to various types of estrogen/progestin formulations. Premenopausal women, using oral contraceptives containing a relatively low dose of estrogen combined with a medium or high dose of progestin (Norlestrin, Ovral, or Demulen) had a 24 per cent higher median concentration of low-density-lipoprotein cholesterol than did those not using hormones (P less than 0.05). Women using oral contraceptives that are high in estrogen and low in progestin (Enovid or Oracon) had significantly higher concentrations of high-density-lipoprotein cholesterol than did nonusers; those using Ovral, a low-estrogen and high-progestin formulation, had significantly lower levels of high-density-lipoprotein cholesterol. In postmenopausal women the use of estrogen was associated with concentrations of low-density-lipoprotein cholesterol that were 11 to 19 per cent below the levels in postmenopausal women who did not use hormones. The effects of estrogen-progestin balance on low-density and high-density lipoproteins may underlie the increased incidence of stroke and myocardial infarction in women of childbearing age who take oral contraceptives.