SYNTHETIC STUDY TOWARDS CONSTRUCTION OF POTENTIAL SCAFFOLD OF ANTITUMOR AGENTS ANDRASTINS
SYNTHETIC STUDY TOWARDS CONSTRUCTION OF POTENTIAL SCAFFOLD OF ANTITUMOR AGENTS ANDRASTINS
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抗肿瘤药安德拉斯汀潜在支架构建的综合研究
DOI：
10.3987/com-16-s(s)2
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发表时间：
2017
期刊：
影响因子：
0.6
通讯作者：
Matsuya Yuji
中科院分区：
文献类型：
--
作者：
Shuqiang Yin;Sugimoto Kenji;Nemoto Hideo;Matsuya Yuji
-为了构建潜在的抗癌药物和类固醇支架，研究了反式熔融AB环与D环连接的三烯的分子内Diels-Alder反应。在回流甲苯中的反应得到了所需的顺式稠合氢化物骨架，其相对立体化学成分由X射线结晶学分析明确确定。
– For a construction of potential scaffold of antitumor agents andrastins, intramolecular Diels-Alder reaction of the triene composed of trans -fused AB ring with tethered D ring was examined. The reaction in refluxing toluene afforded a desired cis -fused hydrindane skeleton, the relative stereochemistries of which were unambiguously determined by X-ray crystallographic analysis.
影响因子：
16.6
作者：
Staben, Steven T.;Kennedy-Smith, Joshua J.;Toste, F. Dean
通讯作者：
Toste, F. Dean