Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery
Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery
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DOI：
10.1016/j.powtec.2007.03.046
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发表时间：
2007-09-05
影响因子：
5.2
通讯作者：
Birchall, J. C.
中科院分区：
文献类型：
--
作者：
Seville, P. C.;Learoyd, T. P.;Birchall, J. C.
本研究考察了精氨酸、天冬氨酸、亮氨酸、苯丙氨酸和苏氨酸等氨基酸在喷雾干燥粉剂中的分散性促进剂。喷雾干燥产量、抽头密度和Carr指数等参数不能预测雾化性能。此外，虽然大多数氨基酸修饰的粉末表现出适合肺部给药的粒度分布和潜在的低水分含量，但只有亮氨酸修饰的粉末在体外增强了颗粒沉积。综上所述，亮氨酸可用于提高肺部药物喷雾干燥粉末的分散性和雾化性能。(C)2007爱思唯尔B.V保留所有权利。
In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as 'dispersibility enhancers' in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility, and aerosolisation properties of spray-dried powders for pulmonary drug delivery. (c) 2007 Elsevier B.V All rights reserved.