Confirmation of region-specific patterns of gene expression in the human brain
Confirmation of region-specific patterns of gene expression in the human brain
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DOI：
10.1007/s10048-007-0084-2
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发表时间：
2007-08-01
期刊：
影响因子：
2.2
通讯作者：
Turecki, Gustavo
中科院分区：
文献类型：
--
作者：
Ernst, Carl;Sequeira, Adolfo;Turecki, Gustavo
人类的大脑以不同的方式进行划分和分类，但并不存在区域特异性的分子遗传学方法。利用来自18个脑区的12名健康对照受试者的数据，我们对每个受试者进行了使用HG-U133AB和HG-U133 plus 2芯片的微阵列分析，以确定显示区域特异性的分子靶点。以以前发表的数据为指导，我们确认Six3、GPR6、SH3RF2和hSyn为伏隔核的分子标记，伽马氨基丁酸A受体α-6、NIK相关激酶和eomesodermin为小脑的分子标记。
The human brain is divided and categorized in different ways, yet a molecular genetic approach to region specificity does not exist. Using data from 12 healthy control subjects across 18 brain regions, we performed a microarray analysis using both the HG-U133AB and HG-U133 plus 2 chips for each subject to determine molecular targets showing region specificity. Using a previously published data as our guide, we confirm SIX3, GPR6, SH3RF2, and hSyn as molecular markers of the nucleus accumbens and gamma-aminobutyric-acid A receptor alpha-6, Nik-related kinase, and eomesodermin as molecular markers of the cerebellum.