Parallel acceleration for modeling of calcium dynamics in cardiac myocytes.
Parallel acceleration for modeling of calcium dynamics in cardiac myocytes.
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DOI：
10.3233/bme-130946
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发表时间：
2014
影响因子：
1
通讯作者：
Yu Z
中科院分区：
文献类型：
--
作者：
Liu K;Yao G;Yu Z
由于钙释放、缓冲和再摄取引起的时空钙动力学在研究健康和缺陷心肌细胞中的兴奋-收缩（E-C）偶联中起核心作用。在我们以前的工作中，偏微分方程（PDE）已被用来模拟钙动力学与现实的几何形状提取的电子显微镜成像数据。然而，这种模拟的计算成本在单个处理器上非常高。为了缓解这个问题，我们已经加快了钙动力学的数值模拟，通过使用图形处理单元（GPU）。计算性能和模拟精度进行了比较基于单CPU和另一种流行的并行计算技术，OpenMP。
Spatial-temporal calcium dynamics due to calcium release, buffering, and re-uptaking plays a central role in studying excitation-contraction (E-C) coupling in both healthy and defected cardiac myocytes. In our previous work, partial differential equations (PDEs) had been used to simulate calcium dynamics with realistic geometries extracted from electron microscopic imaging data. However, the computational costs of such simulations are very high on a single processor. To alleviate this problem, we have accelerated the numerical simulations of calcium dynamics by using graphics processing units (GPUs). Computational performance and simulation accuracy are compared with those based on a single CPU and another popular parallel computing technique, OpenMP.