Evidence for alternative splicing and developmental regulation of the Drosophila melanogaster Mgat2 (N-acetylglucosaminyltransferase II) gene.

Evidence for alternative splicing and developmental regulation of the Drosophila melanogaster Mgat2 (N-acetylglucosaminyltransferase II) gene.
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果蝇 Mgat2(N-乙酰氨基葡萄糖转移酶 II)基因的选择性剪接和发育调控的证据。

DOI:
10.1016/j.bbrc.2003.11.059
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发表时间:
2003
影响因子:
3.1
通讯作者:
S. Grammenoudi
S. Grammenoudi
中科院分区:
生物学4区
文献类型:
--
作者:
S. G. Tsitilou;S. Grammenoudi

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我们提出了一个分子研究的果蝇Mgat 2基因编码的N-乙酰氨基葡萄糖转移酶II。对两个cDNA克隆的分离和分析表明,该基因是选择性剪接的,产生3.3和2.7kb的两个转录本。两种替代转录本在果蝇主要发育阶段具有发育特异性。黑腹菌推导的氨基酸序列与哺乳动物蛋白的同源性很高,特别是在羧基端。在胚胎和胚胎成虫盘中的原位杂交表明,该基因主要但不完全在脑中表达。
We present a molecular study of the Drosophila melanogaster Mgat2 gene that codes for the N-acetylglucosaminyltransferase II. Isolation and analysis of two cDNA clones indicated that the gene is alternatively spliced, generating two transcripts of 3.3 and 2.7kb. Developmental specificity was observed between the two alternative transcripts during the major developmental stages of D. melanogaster. The deduced amino acid sequences of the two proteins show significant homology to the equivalent mammalian proteins, especially in the carboxyterminal region. In situ hybridizations in embryos and embryonic imaginal discs showed that the gene is expressed mainly but not exclusively in the brain.
DOI: 10.1385/0-89603-248-5:169
发表时间: 1993
影响因子: --
作者:
G. Pfeifer;A. Riggs
通讯作者: G. Pfeifer;A. Riggs
分裂异常延迟(dally)基因:果蝇神经系统胚胎后发育过程中细胞分裂模式所需的一种推定的完整膜蛋白多糖。
DOI: 10.1242/dev.121.11.3687
发表时间: 1995
期刊: Development (Cambridge, England)
影响因子: --
作者:
Nakato,H;Futch,TA;Selleck,SB
通讯作者: Selleck,SB