Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids
Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids
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DOI：
10.1021/acs.orglett.6b02556
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发表时间：
2016-10-07
期刊：
影响因子：
5.2
通讯作者：
Yamaguchi, Junichiro
中科院分区：
文献类型：
--
作者：
Muto, Kei;Hatakeyama, Taito;Yamaguchi, Junichiro
首次报道了钯催化的2-连氮甲酸苯酯与芳基硼酸的脱羰基偶联反应。开发这种脱羰基偶联的关键是使用Pd/dcype作为催化剂。各种各样的2-连氮羧酸酯可以进行本发明的偶联反应以提供2-芳基连氮。结合镍催化的脱羰基偶联反应，我们实现了吡啶二甲酸酯的化学选择性顺序脱羰基偶联合成2，4-二芳基吡啶。
The first palladium-catalyzed decarbonylative coupling of phenyl 2-azinecarboxylates and arylboronic acids is presented. The key for the development of this decarbonylative coupling is the use of Pd/dcype as a catalyst. A wide range of 2-azinecarboxylates can undergo the present coupling reaction to afford 2-arylazines. By combination with previously reported nickel-catalyzed decarbonylative coupling, we achieved a chemoselective sequential decarbonylative coupling of pyridine dicarboxylate to synthesize 2,4-diarylpyridine.