Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages
Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages
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DOI：
10.1016/j.bmcl.2015.09.044
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发表时间：
2015-11-15
影响因子：
2.7
通讯作者：
Suenaga, Kiyotake
中科院分区：
文献类型：
--
作者：
Iwasaki, Arihiro;Ohno, Osamu;Suenaga, Kiyotake
2014 年，我们从 Lyngbya sp 的海洋蓝藻菌群中分离出了 kurahyne，一种含乙炔的脂肽。 Kurahyne 对人类癌细胞表现出生长抑制活性，并诱导 HeLa 细胞凋亡。但其作用方式尚不清楚。为了阐明其作用模式，我们进行了多项基于细胞的测定，并鉴定了 kurahyne 的细胞内靶分子为肌/内质网 Ca2+ ATP 酶 (SERCA)。此外，我们发现 kurahyne 抑制巨噬细胞分化为破骨细胞。 (C) 2015 Elsevier Ltd. 保留所有权利。
In 2014, we isolated kurahyne, an acetylene-containing lipopeptide, from a marine cyanobacterial assemblage of Lyngbya sp. Kurahyne exhibited growth-inhibitory activity against human cancer cells, and induced apoptosis in HeLa cells. However, its mode of action is not yet clear. To elucidate its mode of action, we carried out several cell-based assays, and identified the intracellular target molecule of kurahyne as sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). In addition, we found that kurahyne inhibited the differentiation of macrophages into osteoclasts. (C) 2015 Elsevier Ltd. All rights reserved.