Reduction in non-abstinent WHO drinking risk levels and depression/anxiety disorders: 3-year follow-up results in the US general population
Reduction in non-abstinent WHO drinking risk levels and depression/anxiety disorders: 3-year follow-up results in the US general population
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DOI：
10.1016/j.drugalcdep.2019.01.009
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发表时间：
2019-04-01
影响因子：
4.2
通讯作者：
Hasin, Deborah S.
中科院分区：
文献类型：
--
作者：
Knox, Justin;Scodesb, Jennifer;Hasin, Deborah S.
背景资料：非禁欲饮酒的减少，预测改善个人的感觉或功能，如世界卫生组织（WHO）的饮酒风险水平，可能是有用的结果，在临床试验酒精使用障碍（AUD）。方法：目前饮酒者在美国全国调查（n = 22,005）进行了采访，在2001-02年（第1波）和重新采访3年后（第2波）。世界卫生组织饮酒风险水平，一个4级分类系统（极高风险、高风险、中等风险和低风险饮酒者），使用过去12个月内每天估计的平均乙醇消耗量（克）和DSM-IV定义。抑郁症和焦虑症在两个波进行了评估。Logistic回归用于产生调整后的比值比（aOR），检验第1波和第2波WHO风险水平之间的变化与每个初始第1波风险水平的抑郁和/或焦虑障碍的存在或持续性之间的关联。在第1波极高风险饮酒者中，第2波抑郁症和/或焦虑症的几率较低，这是由WHO风险水平1-，两个或三个水平（aOR = 0.42，0.37，0.67，p值0.04- < .0001），第1波抑郁和/或焦虑障碍患者中抑郁和/或焦虑障碍的持续性也是如此（aOR = 0.37，0.29，0.51，p值0.03- < .0001）。结果是不太一致的参与者最初饮酒在较低的风险levels.Conclusions：在非常高风险的饮酒者，减少世界卫生组织饮酒的风险类别与抑郁症和/或焦虑症的风险较低。这些结果进一步表明，世卫组织风险水平的降低是个人感觉和功能的一个有意义的指标。
Background: Non-abstinent drinking reductions that predict improvement in how individuals feel or function, such as the World Health Organization (WHO) drinking risk levels, may be useful outcomes in clinical trials for alcohol use disorders (AUD).Methods: Current drinkers in a U.S. national survey (n = 22,005) were interviewed in 2001-02 (Wave 1) and re interviewed 3 years later (Wave 2). WHO drinking risk levels, a 4- level categorization system (very-high-risk, high-risk, moderate-risk, and low-risk drinkers) defined using estimated mean ethanol consumption (grams) per day in the prior 12 months, and DSM-IV depressive and anxiety disorders were assessed at both waves. Logistic regression was used to produce adjusted odds ratios (aOR) testing the associations of changes between Wave 1 and Wave 2 WHO risk levels to the presence or persistence of depression and/or anxiety disorder by each initial Wave 1 risk level.Results: Among Wave 1 very-high-risk drinkers, lower odds of depression and/or anxiety disorders at Wave 2 were predicted by reductions in WHO risk levels of one-, two- or three-levels (aOR = 0.42, 0.37, 0.67, p-values 0.04- < .0001), as was the persistence of depression and/or anxiety disorders among those with such disorders at Wave 1 (aOR = 0.37, 0.29, 0.51, p-values.03- < .0001). Results were less consistent for participants initially drinking at lower risk levels.Conclusions: Among very-high-risk drinkers, reductions in the WHO drinking risk categories were associated with lower risk of depression and/or anxiety disorders. These results add to findings indicating reductions in WHO risk levels are a meaningful indicator of how individuals feel and function.