Serum ratio of heart-type fatty acid-binding protein to myoglobin - A novel marker of cardiac damage and volume overload in hemodialysis patients
Serum ratio of heart-type fatty acid-binding protein to myoglobin - A novel marker of cardiac damage and volume overload in hemodialysis patients
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DOI：
10.1159/000068520
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发表时间：
2003-02-01
影响因子：
--
通讯作者：
Shimamoto, K
中科院分区：
文献类型：
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作者：
Furuhashi, M;Ura, N;Shimamoto, K
背景资料：心脏型脂肪酸结合蛋白（hFABP），一个有前途的新的标记物，用于检测急性或持续性心肌损伤的浓度显着影响肾清除率，因此有其在肾功能不全患者的有用性的限制。我们评估了血清hFABP与肌红蛋白的比值（F/M）是否可能是评估血液透析患者心脏损害的有用指标。方法：测定21例血液透析患者血清hFABP和肌红蛋白，计算F/M值。检测心肌标志物（心肌肌钙蛋白T [cTnT]、心钠素[ANP]和脑钠素[BNP]）和超声心动图指标（左心室舒张末期内径[LVDd]、左心室质量指数[LVMI]和下腔静脉内径[IVC]），并与hFABP、肌红蛋白和F/M比值进行比较。结果：血液透析患者血清hFABP和肌红蛋白水平显著升高，血液透析期间下降30 - 40%。血透后F/M值与ANP、BNP、cTnT、LVDd、LVMI、IVC呈显著线性相关，而hFABP、肌红蛋白浓度与此无相关性。结论：血透后F/M值而非hFABP本身浓度可能成为判断血透患者心脏损害和容量超负荷的新指标。版权所有（C）2003 S. Karger AG，巴塞尔。
Background: The concentration of heart-type fatty acid-binding protein (hFABP), a promising novel marker for detection of acute or persistent myocardial damage, is significantly influenced by renal clearance and thus has limitations to its usefulness in patients with renal dysfunction. We evaluated whether the serum ratio of hFABP to myoglobin (F/M) might be a useful marker for assessing cardiac damage in hemodialysis patients. Methods: Serum hFABP and myoglobin were measured, and the value of F/M was calculated in 21 hemodialysis patients. Cardiac markers (cardiac troponin T [cTnT], atrial natriuretic peptide [ANP], and brain natriuretic peptide [BNP]) and echocardiographic indices (left ventricular end-diastolic dimension [LVDd], left ventricular mass index [LVMI], and inferior vena cava [IVC] dimension) were examined and compared with hFABP, myoglobin, and F/M ratios. Results: Serum hFABP and myoglobin levels were significantly elevated in hemodialysis patients and reduced by 30-40% during hemodialysis. The value of F/M after hemodialysis, but not the concentration of hFABP or myoglobin, had significant linear correlations with ANP, BNP, cTnT, LVDd, LVMI, and IVC. Conclusion: The value of F/M after hemodialysis, but not the concentration of hFABP itself, might be a newly useful marker for estimation of cardiac damage and volume overload in hemodialysis patients. Copyright (C) 2003 S. Karger AG, Basel.