Ewing Sarcoma Demonstrates Racial Disparities in Incidence-related and Sex-related Differences in Outcome An Analysis of 1631 Cases From the SEER Database, 1973-2005
Ewing Sarcoma Demonstrates Racial Disparities in Incidence-related and Sex-related Differences in Outcome An Analysis of 1631 Cases From the SEER Database, 1973-2005
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DOI：
10.1002/cncr.24388
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发表时间：
2009-08-01
期刊：
影响因子：
6.2
通讯作者：
Scully, Sean P.
中科院分区：
文献类型：
--
作者：
Jawad, Muhammad U.;Cheung, Michael C.;Scully, Sean P.
背景：先前关于尤文肉瘤队列的报道表明，不同种族的发病率存在差异。然而，据作者所知，这一发现从未在以人群为基础的数据库中进行过测试，种族对临床结果的影响以及按种族分组的已知危险因素的重要性尚未报道。方法：1973年至2005年间确诊的尤文肉瘤患者在监测、流行病学和最终结果数据库中进行鉴定。患者的人口学和临床特征；发病率；诊断的年份；肿瘤的位置、肿瘤的大小和诊断时的疾病阶段；治疗(S)；死亡原因；和生存。采用Kaplan-Meier、LOG-RANK和COX回归分析各预后因素的意义。结果：按种族划分的发病率显示，高加索人的发病率最高(0.155)，其次是亚洲人/太平洋岛民(0.082)和非裔美国人(0.017)。高加索人和非裔美国人之间的发病率差异是9倍且显著(P<；.001)。尤文肉瘤的发病率在过去30年中在高加索人中有所增加(P<；0.05)。生存没有受到种族的影响。局部疾病分期、附件骨骼原发肿瘤位置和肿瘤大小
BACKGROUND: Previous reports of Ewing sarcoma cohorts suggested that there is a difference in incidence according to racial origin. However, to the authors' knowledge, this finding has never been tested in a population-based database, and the impact of race on clinical outcome and the significance of known risk factors stratified to racial groups have not been reported. METHODS: Patients who had Ewing sarcoma diagnosed between 1973 and 2005 were identified in the Surveillance, Epidemiology, and End Results database. Patient demographic and clinical characteristics; incidence; year of diagnosis; tumor location, tumor size, and disease stage at diagnosis; treatment(s); cause of death; and survival were extracted. Kaplan-Meier, log-rank, and Cox regressions were used to analyze the significance of prognostic factors. RESULTS: Race-specific incidence indicated that Caucasians have the highest incidence (0.155), followed by Asians/Pacific Islanders (0.082), and African Americans (0.017). The difference in incidence between Caucasians and African Americans was 9-fold and significant (P < .001). The incidence of Ewing sarcoma increased over the past 3 decades among Caucasians (P < .05). Survival was not impacted by race. Local disease stage, primary tumor location in the appendicular skeleton, and tumor size