Functional differentiation along the anterior-posterior axis of the hippocampus in monkeys
Functional differentiation along the anterior-posterior axis of the hippocampus in monkeys
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DOI：
10.1152/jn.1998.80.2.1002
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发表时间：
1998-08-01
影响因子：
2.5
通讯作者：
Gross, CG
中科院分区：
文献类型：
--
作者：
Colombo, M;Fernandez, T;Gross, CG
我们测试了灵长类动物的海马是否沿着其前后轴功能异质。两只猴子接受了空间和非空间记忆任务的训练，并注意到前、中、后海马中空间和非空间延迟活动的发生率。空间延迟活动（在延迟期后的样品刺激的空间记忆任务的活动）是更常见的后部比前部海马，而非空间延迟活动（在延迟期后的样品刺激的非空间记忆任务的活动）均匀分布在整个海马。此外，在前海马的延迟神经元表现出扇贝延迟活动，而在中，后海马没有。这些研究结果表明，海马是功能异质性和后区可能是更重要的处理空间信息，而前区可能是更重要的指导或编码运动的空间点。
We tested whether the primate hippocampus was functionally heterogenous along its anterior-posterior axis. Two monkeys were trained on both a spatial and nonspatial memory task and the incidence of spatial and nonspatial delay activity in the anterior, middle, and posterior hippocampus was noted. Spatial delay activity (activity in the delay period after the sample stimulus on the spatial memory task) was more common in the posterior than the anterior hippocampus, whereas nonspatial delay activity (activity in the delay period after the sample stimulus on the nonspatial memory task) was evenly distributed throughout the hippocampus. Furthermore, delay neurons in the anterior hippocampus exhibited scalloping delay activity, whereas those In the middle and posterior hippocampus did not. These findings suggest that the hippocampus is functionally heterogeneous and that the posterior regions may be more important for processing spatial information, whereas the anterior regions may be more important for directing or coding movements to points in space.