Epidermolysis bullosa acquisita: ultrastructural and immunological studies.
Epidermolysis bullosa acquisita: ultrastructural and immunological studies.
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DOI：
10.1111/1523-1747.ep12526124
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发表时间：
1981-04
期刊：
影响因子：
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通讯作者：
Hideo Yaoita;R. A. Briggaman;T. J. Lawley;Thomas T. Provost;Stephen I. Katz
中科院分区：
文献类型：
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作者：
Hideo Yaoita;R. A. Briggaman;T. J. Lawley;Thomas T. Provost;Stephen I. Katz
应用免疫荧光、常规电镜和免疫电镜技术对4例获得性大疱性表皮病进行了研究。免疫荧光研究表明，线性免疫球蛋白和补体沉积沿着真皮表皮交界处。这些发现与大疱性类天疱疮患者皮肤中所见相似。免疫电子显微镜研究表明，免疫反应物被定位在下面的subbasal层锚定纤维区的基底膜，从而清楚地区分免疫病理学的大疱性类天疱疮获得性大疱性表皮。间接免疫电镜结果表明，受影响患者的表皮基底细胞可能分泌抗体结合的真皮物质。
Four patients with epidermolysis bullosa acquisita were investigated using immunofluorescence, routine electron microscopic and immunoelectron microscopic techniques. Immunofluorescence studies demonstrated linear immunoglobulin and complement deposition along the dermal-epidermal junction. These findings are similar to those seen in skin of patients with bullous pemphigoid. Immunoelectron microscopic studies demonstrated that the immunoreactants were localized below the subbasal lamina-anchoring fibril zone of the basement membrane, thereby clearly distinguishing the immunopathology of epidermolysis bullosa acquisita from that seen in bullous pemphigoid. Indirect immunoelectron microscopic findings suggest that epidermal basal cells of affected patients may secrete the dermal substances to which the antibodies bind.