Multifunctional nanoparticles as theranostic agents for therapy and imaging of breast cancer
Multifunctional nanoparticles as theranostic agents for therapy and imaging of breast cancer
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DOI：
10.1016/j.jphotobiol.2020.112110
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发表时间：
2021-04-14
影响因子：
5.4
通讯作者：
Kolios, Michael C.
中科院分区：
文献类型：
--
作者：
Fernandes, Donald A.;Fernandes, Dennis D.;Kolios, Michael C.
在过去的十年里，纳米技术有了重大的发展，特别是在成像和治疗的结合应用（治疗学）方面。纳米乳液（NEs）的核心或外壳可以装载各种治疗剂，包括用于有效治疗的低溶解度药物，或用于特定成像方式（例如，MRI，荧光）的各种显像剂。在这项工作中，全氟己烷（PFH） NEs被合成用于治疗应用，并与二氧化硅包覆的金纳米颗粒（scAuNPs）耦合，以增加激光诱导汽化（即光学液滴汽化）时PFH气泡的产生。这些纳米颗粒的吸收特性产生的局部热（用于提供光声信号）也可用于治疗癌症，而不会显著损害附近的健康组织。这些PFH-NEs的治疗潜力用于肿瘤的对比成像和作为治疗目的的药物输送载体，在体外和体内系统中使用光声、超声和荧光成像模式的组合得到了证明。PFH-NEs与scAuNPs偶联，附着在癌细胞膜上并内化在癌细胞内的能力，在临床环境中通过汽化直接诱导癌细胞死亡的靶向化疗应用中令人鼓舞。
Over the last decade, there has been significant developments in nanotechnology, in particular for combined imaging and therapeutic applications (theranostics). The core or shell of nanoemulsions (NEs) can be loaded with various therapeutic agents, including drugs with low solubility for effective treatment, or various imaging agents for specific imaging modalities (e.g., MRI, fluorescence). In this work, perfluorohexane (PFH) NEs were synthesized for theranostic applications and were coupled to silica coated gold nanoparticles (scAuNPs) to increase the generation of PFH bubbles upon laser induced vaporization (i.e., optical droplet vaporization). The localized heat generated from the absorption properties of these nanoparticles (used to provide photoacoustic signals) can also be used to treat cancer without significantly damaging nearby healthy tissues. The theranostic potential of these PFH-NEs for contrast imaging of tumors and as a drug-delivery vehicle for therapeutic purposes were demonstrated for both in vitro and in vivo systems using a combination of photoacoustic, ultrasound and fluorescence imaging modalities. The ability of PFH-NEs to couple with scAuNPs, attach to the membranes of cancer cells and internalize within cancer cells, are encouraging for targeted chemotherapeutic applications for directly inducing cancer cell death via vaporization in clinical settings.