Arterial stiffening precedes systolic hypertension in diet-induced obesity.
Arterial stiffening precedes systolic hypertension in diet-induced obesity.
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DOI：
10.1161/hypertensionaha.113.01744
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Seta F
中科院分区：
文献类型：
--
作者：
Weisbrod RM;Shiang T;Al Sayah L;Fry JL;Bajpai S;Reinhart-King CA;Lob HE;Santhanam L;Mitchell G;Cohen RA;Seta F
Stiffening of conduit arteries is a risk factor for cardiovascular morbidity. Aortic wall stiffening increases pulsatile hemodynamic forces that are detrimental to the microcirculation in highly perfused organs such as the heart, brain and kidney. Arterial stiffness is associated with hypertension but presumed to be due to an adaptive response to increased hemodynamic load. In contrast, a recent clinical study found that stiffness precedes and may contribute to the development of hypertension, although the mechanisms contributing to hypertension are unknown. Here we report that in a diet-induced model of obesity, arterial stiffness, measured in vivo, develops within one month of the initiation of the diet and precedes the development of hypertension by five months. Diet-induced obese mice recapitulate the metabolic syndrome and are characterized by inflammation in visceral fat and aorta. Normalization of the metabolic state by weight loss returned arterial stiffness and blood pressure to normal. Our findings support the hypothesis that arterial stiffness is a cause, rather than a consequence of hypertension.
