Dopaminergic neurons
Dopaminergic neurons
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DOI：
10.1016/j.biocel.2004.09.009
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发表时间：
2005-05-01
影响因子：
4
通讯作者：
Andersen, JK
中科院分区：
文献类型：
--
作者：
Chinta, SJ;Andersen, JK
中脑的多巴胺能神经元是哺乳动物中枢神经系统中多巴胺（DA）的主要来源。他们的损失与最突出的人类神经系统疾病之一，帕金森病（PD）有关。多巴胺能神经元存在于大脑的“苛刻”区域，即黑质的黑质，其富含DA，并且含有氧化还原可用的神经黑色素和高铁含量。虽然它们的数量很少，但这些多巴胺能神经元在控制多种大脑功能中发挥重要作用，包括自主运动和广泛的行为过程，如情绪，奖励，成瘾和压力。对参与大脑中多巴胺能神经元生成的发育途径的研究已经鉴定了几种特异性转录因子，包括Nurr 1，Lmx1b和Pitx 3，所有这些都显示出在中脑多巴胺能系统的发育中很重要。这些多巴胺能神经元的选择性变性导致PD，但这种黑质细胞损失的确切原因仍不清楚。(c)2004爱思唯尔有限公司保留所有权利。
Dopaminergic neurons of the midbrain are the main source of dopamine (DA) in the mammalian central nervous system. Their loss is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons are found in a 'harsh' region of the brain, the substantia nigra pars compacta, which is DA-rich and contains both redox available neuromelanin and a high iron content. Although their numbers are few, these dopaminergic neurons play an important role in the control of multiple brain functions including voluntary movement and a broad array of behavioral processes such as mood, reward, addiction, and stress. Studies into the developmental pathways which are involved in the generation of dopaminergic neurons in the brain have led to the identification of several specific transcription factors including Nurr1, Lmx1b and Pitx3, all shown to be important in the development of the mesencephalic dopaminergic system. The selective degeneration of these dopaminergic neurons in the substantia nigra pars compacta leads to PD but the exact cause for this nigral cell loss is still unknown. (c) 2004 Elsevier Ltd. All rights reserved.