Luminescent iminophosphorane gold, palladium and platinum complexes as potential anticancer agents.
Luminescent iminophosphorane gold, palladium and platinum complexes as potential anticancer agents.
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DOI：
10.1039/c4qi00003j
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发表时间：
2014
影响因子：
7
通讯作者：
Contel M
中科院分区：
文献类型：
--
作者：
Frik M;Jiménez J;Vasilevski V;Carreira M;de Almeida A;Gascón E;Benoit F;Sanaú M;Casini A;Contel M
合成了一系列由8-氨基喹啉[Ph_3P = N-C_9 H_6 N]（1）衍生的亚氨基膦配体与金（III）、钯（II）和铂（II）的配合物，并对其结构进行了表征。在适当的条件下，配位钯（II）和铂（II）化合物可进一步通过PPh 3片段的苯基的C-H活化得到稳定的环化内型物种[M{κ3-C，N，N-C6 H4（PPh 2 = N8-C9 H6 N}Cl]（M = Pd，Pt）.亚氨基膦1和新的金属配合物在室温下在DMSO或DMSO：H2O（1：1混合物）溶液中发光。已在人卵巢癌细胞系（A2780 S）、人肺癌细胞（A-549）和非致瘤性人胚肾细胞系（HEK-293 T）中评价了化合物的抗增殖特性。大多数化合物对卵巢癌细胞系的毒性大于对非致瘤细胞系的毒性。新的复合物与人血清白蛋白（HSA）的相互作用比顺铂更快。化合物与DNA相互作用的研究表明，在某些情况下，它们基于与顺铂不同的作用机制在体外发挥抗癌作用。发光d-金属亚氨基膦配合物作为不与DNA相互作用的卵巢癌细胞系的有效细胞毒性剂
A series of coordination gold(III), palladium(II), and platinum(II) complexes with a luminescent iminophosphorane ligand derived from 8-aminoquinoline [Ph3P=N-C9H6N] (1), have been synthesized and structurally characterized. The coordination palladium(II) and platinum(II) compounds can evolve further, under appropriate conditions, to give stable cyclometalated endo species [M{κ3-C,N,N-C6H4(PPh2=N-8-C9H6N}Cl] (M = Pd, Pt) by C-H activation of the phenyl group of the PPh 3 fragment. Iminophosphorane 1 and the new metallic complexes are luminescent in DMSO or DMSO:H2O (1:1 mixture) solutions at RT. The compounds have been evaluated for their antiproliferative properties in a human ovarian cancer cell line (A2780S), in human lung cancer cells (A-549) and in a non-tumorigenic human embryonic kidney cell line (HEK-293T). Most compounds have been more toxic to the ovarian cancer cell line than to the non-tumorigenic cell line. The new complexes interact with human serum albumin (HSA) faster than cisplatin. Studies of the interactions of the compounds with DNA indicate that, in some cases, they exert anticancer effects in vitro based on different mechanisms of action with respect to cisplatin. Luminescent d metals iminophosphorane complexes as potent cytotoxic agents on ovarian cancer cell lines which do not interact with DNA