Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole
Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole
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DOI：
10.1136/vr.160.26.891
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发表时间：
2007-06-30
影响因子：
2.2
通讯作者：
Aspegren, J. C.
中科院分区：
文献类型：
--
作者：
Granholm, M.;McKusick, B. C.;Aspegren, J. C.
在一项随机、双盲、多中心临床研究中，在牙科护理、放射学检查和耳炎治疗等手术期间，对212只犬静脉或肌内注射右美托咪定或美托咪定。治疗后3小时评估镇静、镇痛和心肺参数以及体温。手术完成后，约一半的犬肌内注射阿替美唑，其他犬自行恢复。右美托咪定和美托咪定的临床效果相似，97%的病例成功完成了手术。不良副作用很少，但包括镇静时间延长、体温过低、呼吸暂停和心动过缓;阿替美唑给药后未观察到不良反应，阿替美唑有效逆转了右美托咪定和美托咪定的所有临床作用。
Two hundred and twelve dogs were treated either intravenously or intramuscularly with either dexmedetomidine or medetomidine in a randomised double-blinded multicentre clinical study during procedures such as dental care, radiography and otitis treatment. Sedative, analgesic and cardiorespiratory parameters and body temperature were assessed for three hours after the treatments. Approximately half the dogs were given atipamezole intramuscularly after the completion of the procedure, and the other dogs were allowed to recover spontaneously. Dexmedetomidine and medetomidine induced similar clinical effects, and the procedure was completed successfully in 97 per cent of cases. There were few adverse side effects, but they included prolonged sedation, hypothermia, apnoea and bradycardia; no adverse effects were observed after the administration of atipamezole, which effectively reversed all the clinical effects of dexmedetomidine and medetomidine.