Structures and solid-state dynamics of one-dimensional water chains stabilized by imidazole channels
Structures and solid-state dynamics of one-dimensional water chains stabilized by imidazole channels
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DOI：
10.1002/anie.200352157
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发表时间：
2003-01-01
影响因子：
16.6
通讯作者：
Buchanan, RM
中科院分区：
文献类型：
--
作者：
Cheruzel, LE;Pometun, MS;Buchanan, RM
一维(1D)水链结构构成了水的一种潜在的重要形式，但人们对此知之甚少。[1]许多基本的生物过程[2-9]似乎取决于水链的独特性质。例如，水链可能通过起到“质子线”的作用来帮助质子通过膜的转移。[10A]这种行为由膜蛋白gricidin A(Ga)[2]说明，其中质子根据格洛特斯传递机制[10b]沿着水分子的单一链条跳跃，[11]或者以H9O4+[12]或H5O2+[13]离子水团的形式迁移。[14]此外，水链似乎对植物叶绿体类囊体膜和线粒体ATPase，[3]和碳酸氢酶II，[3]的细胞色素b6f复合体中的质子途径很重要。[4]以及氧化还原蛋白，如细胞色素氧化酶、细菌视紫红质[6]和球形红杆菌的光合作用反应中心。[7]膜水囊中也发现了水链，这对烟碱受体M2d5[8]和甲型流感M2病毒的功能都很重要。与散装水或冰不同，[15]一维水链似乎是通过链上相邻水分子之间的强氢键以及水分子与与通道相关的给体-受体基团之间的氢键来稳定的。[2，8-9]最近，我们发现某些咪唑类化合物稳定了与上述生物结构相关的无限的一维水链。在此，我们描述了水合化合物的晶体结构和
One-dimensional (1D) water chain structures constitute a potentially important form of water that is poorly understood.[1] Many fundamental biological processes [2–9] appear to depend on the unique properties of water chains. For example, water chains may assist in proton translocation through membranes by functioning as “proton wires”.[10a] Such behavior is illustrated by the membrane protein gramicidin A (gA)[2] in which protons are envisioned [10b] to either hop along a single-file chain of water molecules according to the Grotthuss relay mechanism,[11] or migrate as H9O4+[12] or H5O2+[13] ionic water clusters.[14] In addition, water chains appear to be important to the proton pathways in the cytochrome b6f complex of plant chloroplast thylakoid membrane and mitochondrial ATPase,[3] and carbonic anhydrase II,[4] as well as in redox proteins such as cyctochrome oxidase,[5] bacteriorhodopsin,[6] and the photosynthetic reaction center of Rhodobacter sphaeroides.[7] Water chains are also found in membrane aquapores, which are important to the function of the nicotinic receptor M2d5[8] as well as the influenza A M2 virus.[9]Curiously, little is known of the structural constraints required in stabilizing 1D water chains. Unlike bulk water or ice,[15] 1D water chains appear to be stabilized by strong H-bonding between neighboring water molecules along the chain as well as H-bonding between water molecules and donor–acceptor groups associated with channels.[2, 8–9] Recently, we have discovered that certain imidazole compounds stabilize infinite 1D water chains relevant to the biological structures mentioned above. Herein we describe the crystal structures of the hydrated compounds and