COMPETITIVE IN-VIVO PROLIFERATION OF FETAL AND ADULT HEMOPOIETIC CELLS IN LETHALLY IRRADIATED MICE
COMPETITIVE IN-VIVO PROLIFERATION OF FETAL AND ADULT HEMOPOIETIC CELLS IN LETHALLY IRRADIATED MICE
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DOI：
10.1002/jcp.1040790214
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发表时间：
1972-01-01
影响因子：
5.6
通讯作者：
PAPWORTH, DS
中科院分区：
文献类型：
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作者：
MICKLEM, HS;OGDEN, DA;PAPWORTH, DS
用染色体标记技术研究了22周龄成人骨髓和14-18天胎肝来源的造血细胞群体在致死剂量照射后的相对增殖能力。虽然一开始在注入的集落形成单位(干细胞)数量方面处于劣势，但在几周的时间里，胎肝来源的群体在髓系和淋巴组织中的相对数量稳步增加，直到达到平台期。这表明，平均而言，胎儿肝脏中的干细胞具有比骨髓中更高的内在自我更新能力，这种能力在移植后约10周内降至成人水平。
The relative proliferative capacity of haematopoietic cell populations derived from 22‐week‐old adult bone marrow and 14–18 day foetal liver has been studied in lethally irradiated syngeneic recipients by means of chromosome markers. Although starting at a disadvantage in terms of the number of colony‐forming units (stem cells) injected, the foetal liver‐derived populations steadily increased their relative numbers in the myeloid and lymphoid tissues over a period of several weeks until a plateau was reached. It is suggested that stem cells in foetal liver have, on average, a higher intrinsic capacity for self‐renewal than do those in bone marrow, and that this capacity falls to the adult level within about ten weeks of transfer.