Needle-Type Imager Sensor With Band-Pass Composite Emission Filter and Parallel Fiber-Coupled Laser Excitation

Needle-Type Imager Sensor With Band-Pass Composite Emission Filter and Parallel Fiber-Coupled Laser Excitation
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具有带通复合发射滤光片和并行光纤耦合激光激励的针式成像传感器

DOI:
10.1109/tcsi.2019.2959592
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发表时间:
2020
期刊:
IEEE Transactions on Circuits and Systems I: Regular Papers
影响因子:
--
通讯作者:
Ohta Jun
Ohta Jun
中科院分区:
--
文献类型:
--
作者:
Rustami Erus;Sasagawa Kiyotaka;Sugie Kenji;Ohta Yasumi;Haruta Makito;Noda Toshihiko;Tokuda Takashi;Ohta Jun

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本文介绍了一种植入式荧光系统与复合发射滤波器和光纤耦合激光激发。短通干涉滤光片和吸收滤光片的复合结构表现出在510和570 nm之间的带通光谱,其接近于绿色荧光蛋白(GFP)发射。通过低数值孔径光纤利用蓝色激光获得高质量的激发光。这种耦合方法有益于在特定区域中递送窄光谱和可控的照射光,以最小化来自组织的自发荧光。通过成像发射实验验证了所制作的无透镜系统的性能。所提出的装置是能够感知荧光发射的微球和GFP显着。
This paper presents an implantable fluorescence system with a composite emission filter and fiber-coupled laser excitation. The composite structure of the short-pass interference filter and absorption filters exhibited a band-pass spectrum between 510 and 570 nm, which is close to green fluorescent protein (GFP) emission. A high-quality excitation light was achieved by utilizing a blue laser through a low-numerical-aperture optical fiber. This coupling method is beneficial in delivering a narrow spectrum and controllable irradiation light in a specific area to minimize auto-fluorescence from the tissue. The fabricated lensless system performance is experimentally validated by imaging emission. The proposed device is capable of perceiving fluorescence emission from microspheres and GFP noticeably.
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发表时间: --
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影响因子: 1.1
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