Wireless Chemical Sensing Scheme using Ultrasonic Imaging of Silica-Particle-Embedded Hydrogels (Silicagel)
Wireless Chemical Sensing Scheme using Ultrasonic Imaging of Silica-Particle-Embedded Hydrogels (Silicagel)
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DOI：
10.1016/j.snb.2017.12.085
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发表时间：
2018-04-15
影响因子：
8.4
通讯作者：
Ziaie, B.
中科院分区：
文献类型：
--
作者：
Park, J. H.;Kim, A.;Ziaie, B.
在本文中，我们介绍了一种无线化学传感技术，其特点是超声成像的二氧化硅珠嵌入水凝胶，命名为“硅胶”。通过在水凝胶网络内掺入二氧化硅珠，其响应于环境刺激的体积变化可以通过超声成像远程询问，或者通过直接测量其尺寸（硅胶的横截面）或者间接评估背散射波强度。不同尺寸（4和2毫米立方体）和浓度（0.05和0.1 w/v%）的硅胶制造的pH敏感的聚（甲基丙烯酸-共-丙烯酰胺）水凝胶进行了研究，在体外，使用40 MHz的超声成像系统。对于具有4 mm立方体和0.05 w/v%的硅胶（作为代表），其截面传感法的灵敏度为0.83（mm（2）/mm（2））/pH，理论分辨率为0.001 pH;背散射强度法的灵敏度为17.5灰度强度/pH，在最大响应区的分辨率为0.06 pH单位（pH 4 - 6）。预期相同的技术可应用于对其它刺激敏感的水凝胶（例如，葡萄糖、特定离子、生物标记等）。(C)2017 Elsevier B. V.版权所有。
In this paper, we introduce a wireless chemical sensing technique featuring ultrasonic imaging of a silica bead -embedded hydrogel, named "silicagel". By incorporating silica beads within a hydrogel network, its volume change in response to environmental stimuli can be remotely interrogated by ultrasonic imaging, either by directly measuring its dimensions (cross-section of the silicagel) or indirectly evaluating the back-scattered wave intensity. Various sizes (4 and 2 mm cube) and concentrations (0.05 and 0.1 w/v%) of silicagel fabricated with pH-sensitive poly (methacrylic acid-co-acrylamide) hydrogel is studied in vitro, using a 40 MHz ultrasonic imaging system. For the silicagel with 4 mm cube and 0.05 w/v% (as a representative), its cross-section sensing method results in a sensitivity of 0.83 (mm(2)/mm(2))/pH with a theoretical resolution of 0.001 pH while back-scattered intensity technique exhibit a sensitivity of 17.5 gray-scale intensity/pH with a resolution of 0.06 pH unit in the maximal response region (between pH 4 and 6). It is anticipated that the same technique can be applied to hydrogels sensitive to other stimuli (e.g., glucose, specific ions, biomarkers, etc.). (C) 2017 Elsevier B.V. All rights reserved.