Use of alternative medicine by women with early-stage breast cancer
Use of alternative medicine by women with early-stage breast cancer
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DOI：
10.1056/nejm199906033402206
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发表时间：
1999-06-03
影响因子：
158.5
通讯作者：
Weeks, JC
中科院分区：
文献类型：
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作者：
Burstein, HJ;Gelber, S;Weeks, JC
背景我们分析了1993年9月至1995年9月期间接受标准治疗的早期乳腺癌妇女使用替代药物的情况。方法从马萨诸塞州参加妇女如何选择癌症治疗研究的妇女队列中招募了480例新诊断的早期乳腺癌患者。替代医学治疗，传统疗法，和健康相关的生活quality进行了examined.Results新使用的替代医学手术后乳腺癌是常见的（报告的妇女的28.1%），这种使用是不相关的选择标准的医学治疗后，我们控制了临床和社会人口学变量。共有10.6%的妇女在被诊断为乳腺癌之前使用过替代医学。手术后开始使用替代医学的妇女报告说，生活质量比从未使用替代医学的妇女差。决定使用替代医学的妇女和没有使用替代医学的妇女的心理健康评分在基线上相似，但手术后三个月，使用替代医学与抑郁症、对癌症复发的恐惧、心理健康和性满意度评分较低、身体症状较多以及症状强度较大独立相关。所有组的妇女报告改善生活质量一年后surgical.Conclusions在新诊断的早期乳腺癌的妇女谁已与标准疗法治疗，新使用的替代医学是一个标志更大的心理社会压力和更差的生活质量。（N Engl J Med 1999; 340：1733-9.）(C)1999年，马萨诸塞州医学会。
Background We analyzed the use of alternative medicine by women who had received standard therapy for early-stage breast cancer diagnosed between September 1993 and September 1995.Methods A cohort of 480 patients with newly diagnosed early-stage breast cancer was recruited from a Massachusetts statewide cohort of women participating in a study of how women choose treatment for cancer. Alternative medical treatments, conventional therapies, and health-related quality of life were examined.Results New use of alternative medicine after surgery for breast cancer was common (reported by 28.1 percent of the women); such use was not associated with choices about standard medical therapies after we controlled for clinical and sociodemographic variables. A total of 10.6 percent of the women had used alternative medicine before they were given a diagnosis of breast cancer. Women who initiated the use of alternative medicine after surgery reported a worse quality of life than women who never used alternative medicine. Mental health scores were similar at base line among women who decided to use alternative medicine and those who did not, but three months after surgery the use of alternative medicine was independently associated with depression, fear of recurrence of cancer, lower scores for mental health and sexual satisfaction, and more physical symptoms as well as symptoms of greater intensity. All groups of women reported improving quality of life one year after surgery.Conclusions Among women with newly diagnosed early-stage breast cancer who had been treated with standard therapies, new use of alternative medicine was a marker of greater psychosocial distress and worse quality of life. (N Engl J Med 1999; 340:1733-9.) (C) 1999, Massachusetts Medical Society.