Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension
Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension
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DOI：
10.1161/circulationaha.113.001873
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发表时间：
2013-10-29
期刊：
影响因子：
37.8
通讯作者：
de Man, Frances S.
中科院分区：
文献类型：
--
作者：
Rain, Silvia;Handoko, M. Louis;de Man, Frances S.
背景：右心室舒张期僵硬度在肺动脉高压中的作用尚未明确。因此，我们研究了PAH patients.Methods和结果的RV舒张僵硬的存在和可能的潜在机制进行了单拍RV压力-容量分析在21例PAH患者和7个对照组研究RV舒张僵硬。数据以平均值SEM表示。PAH患者的RV舒张期刚度（）显著增加（PAH，0.050 +/- 0.005 vs对照组，0.029 +/- 0.003; P
Background The role of right ventricular (RV) diastolic stiffness in pulmonary arterial hypertension (PAH) is not well established. Therefore, we investigated the presence and possible underlying mechanisms of RV diastolic stiffness in PAH patients.Methods and Results Single-beat RV pressure-volume analyses were performed in 21 PAH patients and 7 control subjects to study RV diastolic stiffness. Data are presented as meanSEM. RV diastolic stiffness () was significantly increased in PAH patients (PAH, 0.050 +/- 0.005 versus control, 0.029 +/- 0.003; P