Entrainment in a model of the mammalian circadian oscillator
Entrainment in a model of the mammalian circadian oscillator
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DOI：
10.1177/0748730404269309
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发表时间：
2005-02-01
影响因子：
3.5
通讯作者：
Herzel, H
中科院分区：
文献类型：
--
作者：
Geier, F;Becker-Weimann, S;Herzel, H
为了使生物钟调节的过程的时间适应季节性变化的光周期，必须严格调整生物钟与黄昏或黎明之间的相位关系（“诱导相位”）。作者利用分子哺乳动物昼夜振荡器的数学模型，研究了自由运行周期（T）和PRC形状对夹带相位的影响。他们发现，光诱导的周期基因转录的相位依赖性敏感性（“门控”）使得在不同的光周期下与黄昏或黎明的相位关系恒定。根据自由运行周期T和PRC通过门控的成形，模型昼夜节律振荡器在不同光周期下跟踪光起始或光偏移。研究表明，振荡细胞的夹带相位可以通过调节门控和自由运行周期τ来系统地控制。
To adapt the timing of processes regulated by the circadian clock to seasonally varying photoperiods, the phase relation between the circadian clock and dusk or dawn ("phase of entrainment") must be tightly adjusted. The authors use a mathematical model of the molecular mammalian circadian oscillator to investigate the influence of the free-running period (T) and the shape of the PRC on the phase of entrainment. They find that a phase-dependent sensitivity ("gating") of light-induced period gene transcription enables a constant phase relation to dusk or dawn under different photoperiods. Depending on the free-running period T and on the shaping of the PRC by gating, the model circadian oscillator tracks either light onset or light offset under different photoperiods. The study indicates that the phase of entrainment of oscillating cells can be systematically controlled by regulating both gating and the free-running period tau.