Increasing Trend in Young-Onset Colorectal Cancer in Asia: More Cancers in Men and More Rectal Cancers
Increasing Trend in Young-Onset Colorectal Cancer in Asia: More Cancers in Men and More Rectal Cancers
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亚洲年轻起病的结直肠癌呈上升趋势：男性癌症和直肠癌较多
DOI：
10.14309/ajg.0000000000000133
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发表时间：
2019-02-01
影响因子：
9.8
通讯作者：
Kyaw, Moe H.
中科院分区：
文献类型：
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作者：
Sung, Joseph J. Y.;Chiu, Han-Mo;Kyaw, Moe H.
背景：据报道，年轻发病的结直肠癌（CRC）在西方世界的发病率正在上升。目前还没有以人口为基础的研究来评估整个亚洲的趋势。使用Joinpoint Regression Program量化年轻发病CRC（年龄< 50岁）发病率的幅度和趋势方向，以估计平均年百分比变化（AAPC）。结果：在台湾（1995-2014），男性（结肠癌：4.9-9.7 / 10万；直肠癌：4.0-8.3 / 10万）和女性（结肠癌：5.1-9.7 / 10万；直肠癌：3.8-6.4 / 10万）的年轻发性结直肠癌发病率均显著增加。在韩国（1999-2014），男性（结肠癌：5.0-10.4 / 10万；直肠癌：4.9-14.0 / 10万）和女性（结肠癌：4.1-9.6 / 10万；直肠癌：4.1-9.1 / 10万）的年轻发性CRC发病率均显著增加。最显著的变化是男性直肠癌，台湾地区每年增加3.9% (AAPC + 3.9, 95%可信区间+ 3.3至+4.5,P < 0.05)，韩国每年增加6.0% （AAPC +6.0, 95%可信区间+4.5至+7.6,P < 0.05）。只有日本（男性直肠癌：每10万人中有7.2-10.1例，女性直肠癌：每10万人中有4.7-6.7例）和香港（男性直肠癌：每10万人中有4.4-7.0例）的直肠癌发病率显著上升。结论：年轻发病的CRC发病率增加趋势并不局限于西方国家。这一发现可能对这些国家/地区的CRC筛查计划有启示意义。
BACKGROUND:The incidence of young-onset colorectal cancer (CRC) is reported to be increasing in the Western world. There are no population-based studies assessing the trend across Asia.METHODS:We performed a multinational cohort study involving four Asian countries/regions, namely Taiwan, Korea, Japan, and Hong Kong. The magnitude and direction of trend in the incidence of young-onset CRC (age < 50) were quantified using Joinpoint Regression Program to estimate average annual percentage change (AAPC).RESULTS:In Taiwan (1995-2014), incidence of young-onset CRC significantly increased in both men (colon cancer: 4.9-9.7 per 100,000; rectal cancer: 4.0-8.3 per 100,000) and women (colon cancer: 5.1-9.7 per 100,000; rectal cancer: 3.8-6.4 per 100,000). In Korea (1999-2014), incidence of young-onset CRC significantly increased in both men (colon cancer: 5.0-10.4 per 100,000; rectal cancer: 4.9-14.0 per 100,000) and women (colon cancer: 4.1-9.6 per 100,000; rectal cancer: 4.1-9.1 per 100,000). The most pronounced change was observed with male rectal cancer, increasing by 3.9% per year in Taiwan (AAPC + 3.9, 95% confidence interval + 3.3 to +4.5, P < 0.05) and 6.0% per year in Korea (AAPC +6.0, 95% confidence interval + 4.5 to +7.6, P < 0.05). Only a significant increase in rectal cancer was noted in Japan (male rectal cancer: 7.2-10.1 per 100,000, female rectal cancer 4.7-6.7 per 100,000) and Hong Kong (male rectal cancer: 4.4-7.0 per 100,000).CONCLUSIONS:Increasing trend in young-onset CRC is not limited to the Western world. This finding may have implications on screening program for CRC in these countries/regions.