The bone-fat interface: basic and clinical implications of marrow adiposity.
The bone-fat interface: basic and clinical implications of marrow adiposity.
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DOI：
10.1016/s2213-8587(14)70007-5
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发表时间：
2015-02
影响因子：
44.5
通讯作者：
Rosen, Clifford J.
中科院分区：
文献类型：
--
作者：
Devlin, Maureen J.;Rosen, Clifford J.
肥胖症和骨质疏松症是21世纪最常见的两种慢性疾病。两者都伴随着严重的发病率。在哺乳动物体内，骨骼和脂肪唯一相邻的地方是骨髓。骨髓脂肪组织是一个动态的仓库，可能存在的组成和调节区室。脂肪细胞分泌细胞因子和脂肪因子，刺激或抑制相邻的成骨细胞。骨髓脂肪与其他脂肪库的关系是复杂的，并且可能在调节代谢稳态、造血和成骨中发挥非常独特的作用。了解骨骼和脂肪细胞之间的关系，从相同的祖细胞内的“利基”提供了深入了解与年龄相关的骨质疏松症，糖尿病和肥胖症的病理生理学。
Obesity and osteoporosis are two of the most common chronic disorders of the 21st century. Both are accompanied by significant morbidity. The only place in the mammalian organism where bone and fat lie adjacent to each other is in the bone marrow. Marrow adipose tissue is a dynamic depot that likely exists as both constitutive and regulated compartments. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. The relationship of marrow adipose to other fat depots is complex and may play very distinct roles in modulating metabolic homeostasis, hematopoiesis and osteogenesis. Understanding the relationship between bone and fat cells that arise from the same progenitor within the ‘niche’ provides insight into the pathophysiology of age-related osteoporosis, diabetes mellitus and obesity.